Vazhaikkurichi M Rajendran
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Explore the profile of Vazhaikkurichi M Rajendran including associated specialties, affiliations and a list of published articles.
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41
Citations
696
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Recent Articles
1.
Rajput I, Rajendran V, Nickerson A, Lodge J, Sandle G
Am J Physiol Gastrointest Liver Physiol
. 2024 Sep;
327(5):G701-G710.
PMID: 39226584
Mesenteric ischemia increases gut permeability and bacterial translocation. In human colon, chemical hypoxia induced by 2,4-dinitrophenol (DNP) activates basolateral intermediate conductance K (IK) channels (designated KCa3.1 or KCNN4) and increases...
2.
Nickerson A, Rajendran V
Cell Mol Life Sci
. 2023 Jul;
80(8):209.
PMID: 37458846
The corticosteroid hormone, aldosterone, markedly enhances K secretion throughout the colon, a mechanism critical to its role in maintaining overall K balance. Previous studies demonstrated that basolateral NKCC1 was up-regulated...
3.
Vickers S, Shumar S, Saporito D, Kunovac A, Hathaway Q, Mintmier B, et al.
J Biol Chem
. 2022 Nov;
299(1):102745.
PMID: 36436558
Nudix hydrolase 7 (NUDT7) is an enzyme that hydrolyzes CoA species, is highly expressed in the liver, and resides in the peroxisomes. Peroxisomes are organelles where the preferential oxidation of...
4.
Rhodes R, Singh S, Rajendran V, Walk S, Coon S
J Diabetes Res
. 2022 Feb;
2022:5636499.
PMID: 35224107
Our recent studies have shown that glucose-dependent insulinotropic polypeptide (GIP), but not glucagon-like peptide 1 (GLP-1), augments Na-glucose transporter 1- (SGLT1-) mediated glucose absorption in mouse jejunum. Na-dependent glucose absorption...
5.
Nickerson A, Rajendran V
Am J Physiol Gastrointest Liver Physiol
. 2021 Jun;
321(2):G185-G199.
PMID: 34132108
Recent studies in our lab have shown that the K7 channel activator, flupirtine, inhibits colonic epithelial Cl secretion through effects on submucosal neurons of the enteric nervous system (ENS). We...
6.
Nickerson A, Rajendran V
FASEB J
. 2021 Apr;
35(5):e21606.
PMID: 33908679
Na -K -2Cl cotransporter-1 (NKCC1) facilitates basolateral K and Cl uptake, supporting their efflux across mucosal membranes of colonic epithelial cells. NKCC1 activity has also been shown to be critical...
7.
Nickerson A, Rottgen T, Rajendran V
Am J Physiol Cell Physiol
. 2021 Apr;
320(6):C1074-C1087.
PMID: 33852365
Voltage-gated Kv7 ( family) K channels are expressed in many neuronal populations and play an important role in regulating membrane potential by generating a hyperpolarizing K current and decreasing cell...
8.
Rehman S, Narayanan K, Nickerson A, Coon S, Hoque K, Sandle G, et al.
Am J Physiol Gastrointest Liver Physiol
. 2020 Jun;
319(2):G142-G150.
PMID: 32567323
Transepithelial K absorption requires apical K uptake and basolateral K exit. In the colon, apical H-K-ATPase mediates cellular K uptake, and it has been suggested that electroneutral basolateral K exit...
9.
Minor E, Kupec J, Nickerson A, Narayanan K, Rajendran V
Am J Physiol Cell Physiol
. 2019 Nov;
318(2):C263-C271.
PMID: 31721611
Iron deficiency anemia is a common complication of ulcerative colitis (UC) that can profoundly impact quality of life. Most iron absorption occurs in the duodenum via divalent metal transporter 1...
10.
Sarkar P, Saha T, Sheikh I, Chakraborty S, Aoun J, Chakrabarti M, et al.
Am J Physiol Gastrointest Liver Physiol
. 2018 Nov;
316(2):G229-G246.
PMID: 30406698
Whether zinc (Zn) regulates barrier functions by modulating tight-junction (TJ) proteins when pathogens such as Shigella alter epithelial permeability is still unresolved. We investigated the potential benefits of Zn in...