Vasundhara Sharma
Overview
Explore the profile of Vasundhara Sharma including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
187
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0
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Recent Articles
1.
Zhou S, Sosina O, Bovijn J, Laurent L, Sharma V, Akbari P, et al.
Nat Genet
. 2023 Aug;
55(8):1277-1287.
PMID: 37558884
In this study, we leveraged the combined evidence of rare coding variants and common alleles to identify therapeutic targets for osteoporosis. We undertook a large-scale multiancestry exome-wide association study for...
2.
Senitzki A, Safieh J, Sharma V, Golovenko D, Danin-Poleg Y, Inga A, et al.
Nucleic Acids Res
. 2021 Jan;
49(3):1364-1382.
PMID: 33444431
Sequence-specific protein-DNA interactions are at the heart of the response of the tumor-suppressor p53 to numerous physiological and stress-related signals. Large variability has been previously reported in p53 binding to...
3.
Sharma V, Wright K, Epling-Burnette P, Reuther G
Front Immunol
. 2020 Dec;
11:604142.
PMID: 33329600
The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are associated with clonal myelopoiesis, elevated risk of death due to thrombotic complications, and transformation to acute myeloid leukemia (AML). JAK2 inhibitors...
4.
Yue L, Sharma V, Horvat N, Akuffo A, Beatty M, Murdun C, et al.
Blood
. 2019 Nov;
135(3):191-207.
PMID: 31750881
Protein acetylation is an important contributor to cancer initiation. Histone deacetylase 6 (HDAC6) controls JAK2 translation and protein stability and has been implicated in JAK2-driven diseases best exemplified by myeloproliferative...
5.
Guha A, Ahuja D, Das Mandal S, Parasar B, Deyasi K, Roy D, et al.
iScience
. 2019 May;
15:342-359.
PMID: 31103853
Expression of tumor suppressor p53 is regulated at multiple levels, disruption of which often leads to cancer. We have adopted an approach combining computational systems modeling with experimental validation to...
6.
Sharma V, Gupta V, Parmar P, Jain P, Thakran D, Sen R
J Cytol
. 2019 Apr;
36(2):89-93.
PMID: 30992643
Context: Liquid-based cytology (LBC) is being extensively used for the evaluation of both gynecological and non-gynecological specimens. Suspension of cells in monolayer makes better morphological assessment possible. Along with this,...
7.
Mahajan N, Malla P, Bhagwat S, Sharma V, Sarnaik A, Kim J, et al.
Oncotarget
. 2018 Jan;
8(63):106352-106368.
PMID: 29290954
Epigenetic signaling networks dynamically regulate gene expression to maintain cellular homeostasis. Previously, we uncovered that WEE1 phosphorylates histone H2B at tyrosine 37 (pY37-H2B) to negatively regulate global histone transcriptional output....
8.
Kumar P, Sharma V, Atmaram C, Singh B
Environ Sci Pollut Res Int
. 2017 Jan;
24(8):7285-7297.
PMID: 28102497
Soil salinity is a major constraint that limits legume productivity. Pigeonpea is a salt sensitive crop. Seed gamma irradiation at a very low dose (2.5 Gy) is known to enhance...
9.
Sharma V, Monti P, Fronza G, Inga A
FEMS Yeast Res
. 2016 Sep;
16(7).
PMID: 27683095
The observation that human transcription factors (TFs) can function when expressed in yeast cells has stimulated the development of various functional assays to investigate (i) the role of binding site...
10.
Sharma V, Jordan J, Ciribilli Y, Resnick M, Bisio A, Inga A
PLoS One
. 2015 Jul;
10(7):e0130170.
PMID: 26147604
The NF-κB transcription factor family plays a central role in innate immunity and inflammation processes and is frequently dysregulated in cancer. We developed an NF-κB functional assay in yeast to...