Vanivilasini Balachandran
Overview
Explore the profile of Vanivilasini Balachandran including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
12
Citations
434
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Hedger A, Myint W, Lee J, Suchenski-Loustaunau D, Balachandran V, Shaqra A, et al.
bioRxiv
. 2024 Sep;
PMID: 39282427
APOBEC3 (or A3) enzymes have emerged as potential therapeutic targets due to their role in introducing heterogeneity in viruses and cancer, often leading to drug resistance. Inhibiting these enzymes has...
2.
Maiti A, Hedger A, Myint W, Balachandran V, Watts J, Schiffer C, et al.
Nat Commun
. 2022 Nov;
13(1):7117.
PMID: 36402773
APOBEC3 proteins (A3s) are enzymes that catalyze the deamination of cytidine to uridine in single-stranded DNA (ssDNA) substrates, thus playing a key role in innate antiviral immunity. However, the APOBEC3...
3.
Maiti A, Myint W, Delviks-Frankenberry K, Hou S, Kanai T, Balachandran V, et al.
J Mol Biol
. 2020 Oct;
432(23):6042-6060.
PMID: 33098858
APOBEC3G (A3G) is a single-stranded DNA (ssDNA) cytosine deaminase that can restrict HIV-1 infection by mutating the viral genome. A3G consists of a non-catalytic N-terminal domain (NTD) and a catalytic...
4.
Holla S, Dhakshnamoorthy J, Folco H, Balachandran V, Xiao H, Sun L, et al.
Cell
. 2019 Dec;
180(1):150-164.e15.
PMID: 31883795
In eukaryotes, heterochromatin is generally located at the nuclear periphery. This study investigates the biological significance of perinuclear positioning for heterochromatin maintenance and gene silencing. We identify the nuclear rim...
5.
Folco H, McCue A, Balachandran V, Grewal S
Genetics
. 2019 Jul;
213(1):127-141.
PMID: 31278118
The fission yeast is a powerful genetic model system for uncovering fundamental principles of heterochromatin assembly and epigenetic inheritance of chromatin states. Heterochromatin defined by histone H3 lysine 9 methylation...
6.
Vo T, Dhakshnamoorthy J, Larkin M, Zofall M, Thillainadesan G, Balachandran V, et al.
Cell Rep
. 2019 Jul;
28(1):267-281.e5.
PMID: 31269446
In eukaryotic genomes, heterochromatin is targeted by RNAi machinery and/or by pathways requiring RNA elimination and transcription termination factors. However, a direct connection between termination machinery and RNA polymerase II...
7.
Xie G, Vo T, Thillainadesan G, Holla S, Zhang B, Jiang Y, et al.
Nat Commun
. 2019 Jan;
10(1):251.
PMID: 30651569
Gene regulatory mechanisms rely on a complex network of RNA processing factors to prevent untimely gene expression. In fission yeast, the highly conserved ortholog of human ERH, called Erh1, interacts...
8.
Gallagher P, Larkin M, Thillainadesan G, Dhakshnamoorthy J, Balachandran V, Xiao H, et al.
Nat Struct Mol Biol
. 2018 Apr;
25(5):372-383.
PMID: 29686279
Iron metabolism is critical for sustaining life and maintaining human health. Here, we find that iron homeostasis is linked to facultative heterochromatin assembly and regulation of gene expression during adaptive...
9.
Taneja N, Zofall M, Balachandran V, Thillainadesan G, Sugiyama T, Wheeler D, et al.
Mol Cell
. 2017 Mar;
66(1):50-62.e6.
PMID: 28318821
Heterochromatin can be epigenetically inherited in cis, leading to stable gene silencing. However, the mechanisms underlying heterochromatin inheritance remain unclear. Here, we identify Fft3, a fission yeast homolog of the...
10.
Folco H, Chalamcharla V, Sugiyama T, Thillainadesan G, Zofall M, Balachandran V, et al.
Nature
. 2017 Feb;
543(7643):126-130.
PMID: 28199302
Uniparental disomy (UPD), in which an individual contains a pair of homologous chromosomes originating from only one parent, is a frequent phenomenon that is linked to congenital disorders and various...