David Wheeler
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Explore the profile of David Wheeler including associated specialties, affiliations and a list of published articles.
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133
Citations
6910
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Recent Articles
1.
Wang L, Voss R, Pastor V, Cardenas M, Kumar P, Maciaszek J, et al.
Res Sq
. 2025 Feb;
PMID: 39975890
Pediatric acute myeloid leukemia (AML) exhibits distinct genetic characteristics, including unique driver alterations and mutations with prognostic and therapeutic significance. Emerging rare, recurrent genetic abnormalities and their associations with outcomes...
2.
Bond J, Hudson N, Kamath K, Wheeler D, Woodgate S, Oddy V
J Anim Sci
. 2025 Feb;
PMID: 39907549
Thirty-six Merino wethers (10-month-old) were fed ad libitum for 30 days two diets;1) low metabolizable energy diet (LME; 30% lucerne: 70% cereal chaff) and 2) high ME diet (HME; 40%...
3.
Srivastav M, Folco H, Nathanailidou P, Anil A, Vijayakumari D, Jain S, et al.
Nat Commun
. 2025 Jan;
16(1):268.
PMID: 39747188
The assembly of repressive heterochromatin in eukaryotic genomes is crucial for silencing lineage-inappropriate genes and repetitive DNA elements. Paradoxically, transcription of repetitive elements within constitutive heterochromatin domains is required for...
4.
Sahu R, Dhakshnamoorthy J, Jain S, Folco H, Wheeler D, Grewal S
Mol Cell
. 2024 Aug;
84(17):3175-3191.e8.
PMID: 39096900
Heterochromatin enforces transcriptional gene silencing and can be epigenetically inherited, but the underlying mechanisms remain unclear. Here, we show that histone deacetylation, a conserved feature of heterochromatin domains, blocks SWI/SNF...
5.
Chen Y, Nguyen D, Wheeler D, Herron G
Pest Manag Sci
. 2024 Mar;
80(7):3612-3619.
PMID: 38451019
Background: The two-spotted spider mite Tetranychus urticae causes significant damage to ornamental, cotton, sugarcane and horticultural crops in Australia. It has a long history of developing resistance to many acaricides...
6.
Zeng P, Prokopec S, Lai S, Pinto N, Chan-Seng-Yue M, Clifton-Bligh R, et al.
Cell Rep
. 2024 Feb;
43(3):113826.
PMID: 38412093
Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA...
7.
Nathanailidou P, Dhakshnamoorthy J, Xiao H, Zofall M, Holla S, ONeill M, et al.
Proc Natl Acad Sci U S A
. 2024 Jan;
121(6):e2315596121.
PMID: 38285941
Heterochromatin, defined by histone H3 lysine 9 methylation (H3K9me), spreads across large domains and can be epigenetically inherited in a self-propagating manner. Heterochromatin propagation depends upon a read-write mechanism, where...
8.
Folco H, Xiao H, Wheeler D, Feng H, Bai Y, Grewal S
Nucleic Acids Res
. 2023 Dec;
52(4):1688-1701.
PMID: 38084929
Centromeric chromatin plays a crucial role in kinetochore assembly and chromosome segregation. Centromeres are specified through the loading of the histone H3 variant CENP-A by the conserved chaperone Scm3/HJURP. The...
9.
Nimbs M, Champion C, Lobos S, Malcolm H, Miller A, Seinor K, et al.
PeerJ
. 2023 Nov;
11:e16498.
PMID: 38025735
Genomic vulnerability analyses are being increasingly used to assess the adaptability of species to climate change and provide an opportunity for proactive management of harvested marine species in changing oceans....
10.
Bond J, Refshauge G, Newell M, Holman B, Wheeler D, Woodgate S, et al.
Proteomes
. 2023 Sep;
11(3).
PMID: 37755706
The value of crops such as perennial wheat (PW) for grain and grazing compared to conventional wheat (W), or the addition of lucerne to PW (PWL) is still being determined....