Valle Morales
Overview
Explore the profile of Valle Morales including associated specialties, affiliations and a list of published articles.
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14
Citations
220
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Recent Articles
1.
Valdebenito G, Chacko A, Chung C, Sheshadri P, Chi H, OCallaghan B, et al.
Stem Cell Reports
. 2025 Mar;
:102448.
PMID: 40086445
Mutations in mitochondrial DNA cause severe multisystem disease frequently associated with muscle weakness. The m.3243A>G mutation is the major cause of mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS). Experimental...
2.
Fu H, Vuononvirta J, Fanti S, Bonacina F, dAmati A, Wang G, et al.
Nat Metab
. 2025 Feb;
PMID: 40000839
No abstract available.
3.
Karatzia L, Cullen F, Young M, Lam S, Morales V, Bianchi K, et al.
Diabetes
. 2025 Jan;
PMID: 39836371
Diabetes mellitus (DM) leads to a more rapid development of DM cardiomyopathy (dbCM) and progression to heart failure in women than men. Combination of high-fat diet (HFD) and freshly-injected streptozotocin...
4.
Perna L, Salsbury G, Dushti M, Smith C, Morales V, Bianchi K, et al.
Int J Mol Sci
. 2025 Jan;
25(24.
PMID: 39769008
Mitochondrial dysfunction is implicated in the pathogenesis of the neurological condition autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), yet precisely how the mitochondrial metabolism is affected is unknown. Thus, to...
5.
Carpentier J, Freitas M, Morales V, Bianchi K, Bomalaski J, Szlosarek P, et al.
iScience
. 2025 Jan;
28(1):111525.
PMID: 39758821
Pleural mesothelioma is a highly chemotherapy-resistant cancer. Approximately 50% of mesotheliomas do not express argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme in arginine biosynthesis, making arginine depletion with pegylated arginine...
6.
Contento G, Wilson J, Selvarajah B, Plate M, Guillotin D, Morales V, et al.
JCI Insight
. 2024 Sep;
9(18).
PMID: 39315548
Fibrosis is a chronic disease characterized by excessive extracellular matrix production, which leads to disruption of organ function. Fibroblasts are key effector cells of this process, responding chiefly to the...
7.
Fu H, Vuononvirta J, Fanti S, Bonacina F, dAmati A, Wang G, et al.
Nat Metab
. 2023 Oct;
5(11):1969-1985.
PMID: 37884694
T cell activation is associated with a profound and rapid metabolic response to meet increased energy demands for cell division, differentiation and development of effector function. Glucose uptake and engagement...
8.
Simpson R, Praditsuktavorn B, Wall J, Morales V, Thiemermann C, Tremoleda J, et al.
J Trauma Acute Care Surg
. 2023 May;
95(4):481-489.
PMID: 37249511
Background: Cardiac dysfunction (CD) has emerged as a key contributor to delayed organ failure and late mortality in patients surviving the initial traumatic hemorrhagic response. Inflammatory processes are implicated in...
9.
Crosas-Molist E, Graziani V, Maiques O, Pandya P, Monger J, Samain R, et al.
Nat Commun
. 2023 May;
14(1):2740.
PMID: 37217519
Cell migration is crucial for cancer dissemination. We find that AMP-activated protein kinase (AMPK) controls cell migration by acting as an adhesion sensing molecular hub. In 3-dimensional matrices, fast-migrating amoeboid...
10.
Mian S, Philippe C, Maniati E, Protopapa P, Bergot T, Piganeau M, et al.
Sci Transl Med
. 2023 Mar;
15(685):eabn5135.
PMID: 36857430
Patients with myelodysplastic syndrome and ring sideroblasts (MDS-RS) present with symptomatic anemia due to ineffective erythropoiesis that impedes their quality of life and increases morbidity. More than 80% of patients...