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Valery Leytin

Explore the profile of Valery Leytin including associated specialties, affiliations and a list of published articles. Areas
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Articles 24
Citations 502
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Recent Articles
11.
Gyulkhandanyan A, Mutlu A, Freedman J, Leytin V
J Thromb Thrombolysis . 2012 Mar; 33(4):397-411. PMID: 22383127
Apoptosis, or programmed cell death, is a physiological mechanism that serves for controlled deletion of damaged cells. While long attributed exclusively to nucleated cells, over recent years it has been...
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Leytin V
Blood Rev . 2011 Nov; 26(2):51-63. PMID: 22055392
For many years, programmed cell death, known as apoptosis, was attributed exclusively to nucleated cells. Currently, however, apoptosis is also well-documented in anucleate platelets. This review describes extrinsic and intrinsic...
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Leytin V, Allen D, Mutlu A, Gyulkhandanyan A, Mykhaylov S, Freedman J
Lab Invest . 2009 Feb; 89(4):374-84. PMID: 19238135
The role of the mitochondrial permeability transition pore (MPTP) in apoptosis of nucleated cells is well documented. In contrast, the role of MPTP in apoptosis of anucleated platelets is largely...
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Leytin V, Allen D, Mutlu A, Mykhaylov S, Lyubimov E, Freedman J
Br J Haematol . 2008 May; 142(3):494-7. PMID: 18492095
No abstract available.
17.
Leytin V, Mykhaylov S, Starkey A, Allen D, Lau H, Ni H, et al.
Br J Haematol . 2006 Mar; 133(1):78-82. PMID: 16512832
We have previously shown that injection of anti-glycoprotein (GP) IIb induces murine immune thrombocytopenia (ITP) and that intravenous immunoglobulin (IVIg) ameliorates ITP. We hypothesise that murine ITP may be associated...
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Leytin V, Allen D, Gwozdz A, Garvey B, Freedman J
Transfusion . 2004 Sep; 44(10):1487-95. PMID: 15383023
Background: Role of P-selectin (CD62) and glycoprotein (GP) Ibalpha in posttransfusion clearance of platelet concentrates (PCs) is unclear. Study Design And Methods: Platelet (PLT) activation in vitro was determined by...
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Leytin V, Allen D, Mykhaylov S, Mis L, Lyubimov E, Garvey B, et al.
Biochem Biophys Res Commun . 2004 Jun; 320(2):303-10. PMID: 15219827
Recently, it has been discovered that apoptosis of anucleate platelets can be induced by chemical agonists. Other studies demonstrated that mechanical forces (shear stresses) stimulate platelet activation and signaling in...
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Leytin V, Allen D, Garvey B, Freedman J
Transfusion . 2003 Jun; 43(7):983-5. PMID: 12823762
No abstract available.