Valerio Costa
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Explore the profile of Valerio Costa including associated specialties, affiliations and a list of published articles.
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58
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1122
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Recent Articles
11.
Drongitis D, Caterino M, Verrillo L, Santonicola P, Costanzo M, Poeta L, et al.
Hum Mol Genet
. 2022 Jan;
31(11):1884-1908.
PMID: 35094084
X-linked lissencephaly with abnormal genitalia (XLAG) and developmental epileptic encephalopathy-1 (DEE1) are caused by mutations in the Aristaless-related homeobox (ARX) gene, which encodes a transcription factor responsible for brain development....
12.
Cataldi S, Aprile M, Melillo D, Mucel I, Giorgetti-Peraldi S, Cormont M, et al.
Cells
. 2022 Jan;
11(1).
PMID: 35011604
Low-grade chronic inflammation and reduced differentiation capacity are hallmarks of hypertrophic adipose tissue (AT) and key contributors of insulin resistance. We identified PPARGΔ5 as a dominant-negative splicing isoform overexpressed in...
13.
Cataldi S, Costa V, Ciccodicola A, Aprile M
Curr Diab Rep
. 2021 Apr;
21(6):18.
PMID: 33866450
Purpose Of Review: Full and partial synthetic agonists targeting the transcription factor PPARγ are contained in FDA-approved insulin-sensitizing drugs and used for the treatment of metabolic syndrome-related dysfunctions. Here, we...
14.
Terreri S, Mancinelli S, Ferro M, Vitale M, Perdona S, Castaldo L, et al.
Cancers (Basel)
. 2021 Feb;
13(4).
PMID: 33567603
Non-coding RNA transcripts originating from Ultraconserved Regions (UCRs) have tissue-specific expression and play relevant roles in the pathophysiology of multiple cancer types. Among them, we recently identified and characterized the...
15.
Aprile M, Katopodi V, Leucci E, Costa V
Cancers (Basel)
. 2020 Nov;
12(11).
PMID: 33142861
Sequencing-based transcriptomics has significantly redefined the concept of genome complexity, leading to the identification of thousands of lncRNA genes identification of thousands of lncRNA genes whose products possess transcriptional and/or...
16.
Aprile M, Cataldi S, Perfetto C, Ambrosio M, Italiani P, Tate R, et al.
Cells
. 2020 May;
9(5).
PMID: 32455814
Reduced neo-adipogenesis and dysfunctional lipid-overloaded adipocytes are hallmarks of hypertrophic obesity linked to insulin resistance. Identifying molecular features of hypertrophic adipocytes requires appropriate in vitro models. We describe the generation...
17.
Delle Cave D, Di Guida M, Costa V, Sevillano M, Ferrante L, Heeschen C, et al.
Oncogene
. 2020 Apr;
39(21):4271-4285.
PMID: 32291413
Pancreatic stellate cells (PSCs) secrete high levels of transforming growth factor-β1 (TGF-β1) that contributes to the development of pancreatic ductal adenocarcinoma (PDAC). TGF-β1 modulates the expression of L1 cell adhesion...
18.
Malapelle U, Pepe F, Pisapia P, Sgariglia R, Nacchio M, De Luca C, et al.
Front Oncol
. 2020 Mar;
10:236.
PMID: 32219061
Next-generation sequencing (NGS) needs to be validated and standardized to ensure that cancer patients are reliably selected for target treatments. In Italy, NGS is performed in several institutions and harmonization...
19.
Lombardo B, Esposito D, Iossa S, Vitale A, Verdesca F, Perrotta C, et al.
Cytogenet Genome Res
. 2019 May;
158(1):25-31.
PMID: 31055587
Diagnosing a complex genetic syndrome and correctly assigning the concomitant phenotypic traits to a well-defined clinical form is often a medical challenge. In this work, we report the analysis of...
20.
Esposito R, Esposito D, Pallante P, Fusco A, Ciccodicola A, Costa V
Cancer Res
. 2019 Mar;
79(9):2124-2135.
PMID: 30862713
rearrangements as well as and mutations drive differential pathway activation in papillary thyroid carcinomas, leading to different tumor phenotypes and prognoses. Although The Cancer Genome Atlas Consortium has identified tumor...