Valerie Daggett
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Explore the profile of Valerie Daggett including associated specialties, affiliations and a list of published articles.
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164
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4495
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Recent Articles
1.
Nick S, Bryers J, Daggett V
J Biomed Mater Res A
. 2025 Mar;
113(3):e37879.
PMID: 40033797
Microbial biofilms on wounds lead to longer hospital stays, mechanical debridement, and higher mortality. Amyloid fibrils stabilize the bacterial biofilm's extracellular matrix (ECM) and represent a potential anti-biofilm target. As...
2.
Prosswimmer T, Nick S, Bryers J, Daggett V
Int J Mol Sci
. 2024 Jul;
25(13.
PMID: 39000131
Biofilm-associated microbes are 10-1000 times less susceptible to antibiotics. An emerging treatment strategy is to target the structural components of biofilm to weaken the extracellular matrix without introducing selective pressure....
3.
Chen A, Shea D, Daggett V
Sci Rep
. 2024 Apr;
14(1):7946.
PMID: 38575622
Amyloid-beta (Aβ) toxic oligomers are critical early players in the molecular pathology of Alzheimer's disease (AD). We have developed a Soluble Oligomer Binding Assay (SOBA-AD) for detection of these Aβ...
4.
Prosswimmer T, Heng A, Daggett V
Sci Rep
. 2024 Mar;
14(1):5376.
PMID: 38438446
Colocalization of microbial pathogens and the β-amyloid peptide (Aβ) in the brain of Alzheimer's disease (AD) patients suggests that microbial infection may play a role in sporadic AD. Aβ exhibits...
5.
Hsu C, Templin A, Prosswimmer T, Shea D, Li J, Brooks-Worrell B, et al.
Protein Sci
. 2023 Dec;
33(2):e4854.
PMID: 38062941
Type 2 diabetes (T2D) results from insulin secretory dysfunction arising in part from the loss of pancreatic islet β-cells. Several factors contribute to β-cell loss, including islet amyloid formation, which...
6.
Bleem A, Prosswimmer T, Chen R, Hady T, Li J, Bryers J, et al.
Sci Rep
. 2023 Jun;
13(1):9272.
PMID: 37286572
Uropathogenic Escherichia coli account for the largest proportion of nosocomial infections in the United States. Nosocomial infections are a major source of increased costs and treatment complications. Many infections are...
7.
Shea D, Colasurdo E, Smith A, Paschall C, Jayadev S, Keene C, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
119(50):e2213157119.
PMID: 36490316
The formation of toxic Amyloid β-peptide (Aβ) oligomers is one of the earliest events in the molecular pathology of Alzheimer's Disease (AD). These oligomers lead to a variety of downstream...
8.
Prosswimmer T, Daggett V
Open Biol
. 2022 Nov;
12(11):220261.
PMID: 36416010
Amyloid diseases are linked to protein misfolding whereby the amyloidogenic protein undergoes a conformational change, aggregates and eventually forms amyloid fibrils. While the amyloid fibrils and plaques are hallmarks of...
9.
Childers M, Daggett V
Methods Mol Biol
. 2022 Nov;
2552:109-124.
PMID: 36346588
Complex and coordinated dynamics are closely connected with protein functions, including the binding of antibodies to antigens. Knowledge of such dynamics could improve the design of antibodies. Molecular dynamics (MD)...
10.
Childers M, Geeves M, Daggett V, Regnier M
Arch Biochem Biophys
. 2021 Jan;
699:108733.
PMID: 33388313
Muscle myosins are molecular motors that hydrolyze ATP and generate force through coordinated interactions with actin filaments, known as cross-bridge cycling. During the cross-bridge cycle, functional sites in myosin 'sense'...