Valentina C Sladky
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Explore the profile of Valentina C Sladky including associated specialties, affiliations and a list of published articles.
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9
Citations
129
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Recent Articles
1.
Sladky V, Strong M, Tapias-Gomez D, Jewett C, Drown C, Scott P, et al.
Sci Adv
. 2025 Feb;
11(9):eadq2339.
PMID: 40020058
Studying essential genes required for dynamic processes in live mice is challenging as genetic perturbations are irreversible and limited by slow protein depletion kinetics. The auxin-inducible degron (AID) system is...
2.
Sladky V, Strong M, Tapias-Gomez D, Jewett C, Drown C, Scott P, et al.
bioRxiv
. 2024 Jun;
PMID: 38895390
Studying essential genes required for dynamic processes in live mice is challenging as genetic perturbations are irreversible and limited by slow protein depletion kinetics. The first-generation auxin-inducible-degron (AID) system is...
3.
Lambrecht R, Rudolf F, Uckert A, Sladky V, Phan T, Jansen J, et al.
Cell Death Differ
. 2023 Nov;
31(1):119-131.
PMID: 38001256
Paracetamol (acetaminophen, APAP) overdose severely damages mitochondria and triggers several apoptotic processes in hepatocytes, but the final outcome is fulminant necrotic cell death, resulting in acute liver failure and mortality....
4.
Kim J, Wang L, Sladky V, Oh T, Liu J, Trinh K, et al.
Cell Metab
. 2022 Aug;
34(10):1548-1560.e6.
PMID: 36041455
Sterol deficiency triggers SCAP-mediated SREBP activation, whereas hypernutrition together with ER stress activates SREBP1/2 via caspase-2. Whether these pathways interact and how they are selectively activated by different dietary cues...
5.
Sladky V, Akbari H, Tapias-Gomez D, Evans L, Drown C, Strong M, et al.
Genes Dev
. 2022 Aug;
PMID: 35981754
Hepatocyte polyploidization is a tightly controlled process that is initiated at weaning and increases with age. The proliferation of polyploid hepatocytes in vivo is restricted by the PIDDosome-P53 axis, but...
6.
Sladky V, Eichin F, Reiberger T, Villunger A
J Hepatol
. 2021 Jul;
75(5):1177-1191.
PMID: 34228992
A balanced increase in DNA content (ploidy) is observed in some human cell types, including bone-resorbing osteoclasts, platelet-producing megakaryocytes, cardiomyocytes or hepatocytes. The impact of increased hepatocyte ploidy on normal...
7.
Sheikh T, Vasli N, Pastore S, Kharizi K, Harripaul R, Fattahi Z, et al.
Transl Psychiatry
. 2021 Jan;
11(1):1.
PMID: 33414379
PIDD1 encodes p53-Induced Death Domain protein 1, which acts as a sensor surveilling centrosome numbers and p53 activity in mammalian cells. Early results also suggest a role in DNA damage...
8.
Sladky V, Knapp K, Szabo T, Braun V, Bongiovanni L, van den Bos H, et al.
EMBO Rep
. 2020 Nov;
21(12):e50893.
PMID: 33225610
Polyploidization frequently precedes tumorigenesis but also occurs during normal development in several tissues. Hepatocyte ploidy is controlled by the PIDDosome during development and regeneration. This multi-protein complex is activated by...
9.
Sladky V, Villunger A
Cell Death Differ
. 2020 May;
27(7):2037-2047.
PMID: 32415279
The PIDDosome is a multiprotein complex that drives activation of caspase-2, an endopeptidase originally implicated in apoptosis. Yet, unlike other caspases involved in cell death and inflammation, caspase-2 seems to...
10.
Sladky V, Knapp K, Soratroi C, Heppke J, Eichin F, Rocamora-Reverte L, et al.
Dev Cell
. 2020 Jan;
52(3):335-349.e7.
PMID: 31983631
E2F transcription factors control the cytokinesis machinery and thereby ploidy in hepatocytes. If or how these proteins limit proliferation of polyploid cells with extra centrosomes remains unknown. Here, we show...