Vaishali N Patel
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Explore the profile of Vaishali N Patel including associated specialties, affiliations and a list of published articles.
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25
Citations
960
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Recent Articles
1.
Patel V, Aure M, Choi S, Ball J, Lane E, Wang Z, et al.
Nat Commun
. 2024 Oct;
15(1):8784.
PMID: 39389981
No abstract available.
2.
Patel V, Aure M, Choi S, Ball J, Lane E, Wang Z, et al.
Nat Commun
. 2024 Aug;
15(1):7584.
PMID: 39217171
Heparan sulfate (HS) regulation of FGFR function, which is essential for salivary gland (SG) development, is determined by the immense structural diversity of sulfated HS domains. 3-O-sulfotransferases generate highly 3-O-sulfated...
3.
Patel V, Ball J, Choi S, Lane E, Wang Z, Aure M, et al.
Matrix Biol
. 2024 Jun;
133:134-149.
PMID: 38944161
Heparan sulfate (HS) is an important component of the kidney anionic filtration barrier, the glomerular basement membrane (GBM). HS chains attached to proteoglycan protein cores are modified by sulfotransferases in...
4.
Wang Z, Patel V, Song X, Xu Y, Kaminski A, Doan V, et al.
Sci Adv
. 2023 May;
9(21):eadf6232.
PMID: 37235665
is a genetic risk gene associated with Alzheimer's disease (AD) and overexpressed in patients, but how it contributes to the disease progression is unknown. We report the analysis of brain...
5.
Chibly A, Patel V, Aure M, Pasquale M, Martin G, Ghannam M, et al.
NPJ Regen Med
. 2023 Mar;
8(1):17.
PMID: 36966175
The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive. Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin signaling is highly disrupted post-radiation. Neurotrophin...
6.
Chibly A, Aure M, Patel V, Hoffman M
Physiol Rev
. 2022 Mar;
102(3):1495-1552.
PMID: 35343828
Salivary glands produce and secrete saliva, which is essential for maintaining oral health and overall health. Understanding both the unique structure and physiological function of salivary glands, as well as...
7.
Patel V, Pineda D, Berenstein E, Hauser B, Choi S, Prochazkova M, et al.
Matrix Biol
. 2021 Oct;
103-104:37-57.
PMID: 34653670
Heparan sulfate 3-O-sulfotransferases generate highly sulfated but rare 3-O-sulfated heparan sulfate (HS) epitopes on cell surfaces and in the extracellular matrix. Previous ex vivo experiments suggested functional redundancy exists among...
8.
Lombaert I, Patel V, Jones C, Villier D, Canada A, Moore M, et al.
Mol Ther Methods Clin Dev
. 2020 Sep;
18:839-855.
PMID: 32953934
Salivary gland hypofunction causes significant morbidity and loss of quality of life for head and neck cancer patients treated with radiotherapy. Preventing hypofunction is an unmet therapeutic need. We used...
9.
Ferreira J, Zheng C, Lombaert I, Goldsmith C, Cotrim A, Symonds J, et al.
Mol Ther Methods Clin Dev
. 2018 Mar;
9:172-180.
PMID: 29560384
Head and neck cancer patients treated with irradiation often present irreversible salivary gland hypofunction for which no conventional treatment exists. We recently showed that recombinant neurturin, a neurotrophic factor, improves...
10.
Srinivasan P, Patel V, Liu S, Harrington D, Hoffman M, Jia X, et al.
Stem Cells Transl Med
. 2017 Feb;
6(1):110-120.
PMID: 28170182
Radiotherapy for head and neck cancer often has undesirable effects on salivary glands that lead to xerostomia or severe dry mouth, which can increase oral infections. Our goal is to...