Vai Pathak
Overview
Explore the profile of Vai Pathak including associated specialties, affiliations and a list of published articles.
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12
Citations
84
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Recent Articles
1.
Overstreet A, Burge M, Bellar A, McMullen M, Czarnecki D, Huang E, et al.
medRxiv
. 2024 Sep;
PMID: 39281760
Background And Aims: Alcohol-associated hepatitis (AH) is the most life-threatening form of alcohol-associated liver disease (ALD). AH is characterized by severe inflammation attributed to increased levels of ethanol, microbes or...
2.
Tonetti F, Eguileor A, Mrdjen M, Pathak V, Travers J, Nagy L, et al.
Hepatology
. 2024 May;
80(6):1342-1371.
PMID: 38691396
The growing recognition of the role of the gut microbiome's impact on alcohol-associated diseases, especially in alcohol-associated liver disease, emphasizes the need to understand molecular mechanisms involved in governing organ-organ...
3.
Varadharajan V, Ramachandiran I, Massey W, Jain R, Banerjee R, Horak A, et al.
Elife
. 2024 Apr;
12.
PMID: 38648183
Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 gene and advanced liver diseases. Specifically, the common MBOAT7 variant (rs641738) associated with reduced...
4.
Taiwo M, Huang E, Pathak V, Bellar A, Welch N, Dasarathy J, et al.
JCI Insight
. 2024 Apr;
9(9).
PMID: 38573776
Diagnostic challenges continue to impede development of effective therapies for successful management of alcohol-associated hepatitis (AH), creating an unmet need to identify noninvasive biomarkers for AH. In murine models, complement...
5.
Mrdjen M, Huang E, Pathak V, Bellar A, Welch N, Dasarathy J, et al.
Hepatol Commun
. 2023 Oct;
7(11).
PMID: 37820283
Background: Chronic alcohol consumption impairs gut barrier function and perturbs the gut microbiome. Although shifts in bacterial communities in patients with alcohol-associated liver disease (ALD) have been characterized, less is...
6.
Varadharajan V, Ramachandiran L, Massey W, Jain R, Banerjee R, Horak A, et al.
bioRxiv
. 2023 Oct;
PMID: 37808828
Several recent genome-wide association studies (GWAS) have identified single nucleotide polymorphism (SNPs) near the gene encoding membrane-bound -acyltransferase 7 ( ) that is associated with advanced liver diseases. In fact,...
7.
Kim A, Ortega-Ribera M, McMullen M, Bellar A, Taiwo M, Pathak V, et al.
iScience
. 2023 Jun;
26(7):107133.
PMID: 37361874
Alcohol abuse causes increased susceptibility to respiratory syndromes like bacterial pneumonia and viral infections like SARS-CoV-2. Heavy drinkers (HD) are at higher risk of severe COVID-19 if they are also...
8.
Wu X, Fan X, McMullen M, Miyata T, Kim A, Pathak V, et al.
Hepatology
. 2022 Jun;
77(3):902-919.
PMID: 35689613
Background And Aims: Mixed lineage kinase domain-like pseudokinase (MLKL), a key terminal effector of necroptosis, also plays a role in intracellular vesicle trafficking that is critical for regulating liver inflammation...
9.
Singh V, Huang E, Pathak V, Willard B, Allende D, Nagy L
Hepatol Commun
. 2022 Apr;
6(8):2022-2041.
PMID: 35438255
Receptor-interaction protein kinase 3 (RIP3), a critical determinant of the necroptotic pathway of programmed cell death, contributes to injury in murine models of alcohol-associated liver disease (ALD); however, the underlying...
10.
Helsley R, Miyata T, Kadam A, Varadharajan V, Sangwan N, Huang E, et al.
Elife
. 2022 Jan;
11.
PMID: 35084335
There is mounting evidence that microbes residing in the human intestine contribute to diverse alcohol-associated liver diseases (ALD) including the most deadly form known as alcohol-associated hepatitis (AH). However, mechanisms...