Jaividhya Dasarathy
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Explore the profile of Jaividhya Dasarathy including associated specialties, affiliations and a list of published articles.
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43
Citations
803
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Recent Articles
1.
Wu J, Huang E, McMullen M, Singh V, Mrdjen M, Bellar A, et al.
Hepatol Commun
. 2024 Dec;
8(12.
PMID: 39621302
Background: Dichloroacetate (DCA), a pan-pyruvate dehydrogenase kinase inhibitor, ameliorates multiple pathological conditions and tissue injury and shows strong potential for clinical applications. Here, we investigated the preventive effects of DCA...
2.
Overstreet A, Burge M, Bellar A, McMullen M, Czarnecki D, Huang E, et al.
medRxiv
. 2024 Sep;
PMID: 39281760
Background And Aims: Alcohol-associated hepatitis (AH) is the most life-threatening form of alcohol-associated liver disease (ALD). AH is characterized by severe inflammation attributed to increased levels of ethanol, microbes or...
3.
Kim A, McMullen M, Bellar A, Streem D, Dasarathy J, Welch N, et al.
bioRxiv
. 2024 Aug;
PMID: 39211112
Many inflammatory genes in the immune system are clustered in the genome. The 3D genome architecture of these clustered genes likely plays a critical role in their regulation and alterations...
4.
Kim A, Cajigas-Du Ross C, Dasarathy J, Bellar A, Streem D, Welch N, et al.
Metab Target Organ Damage
. 2024 Aug;
2(4).
PMID: 39148503
Aim: Metabolic liver diseases, including alcohol- and non-alcoholic fatty liver diseases (ALD/NAFLD), are characterized by inflammation and decreased ability to prevent infections. Patients with severe alcohol-associated hepatitis (sAH) are particularly...
5.
Varadharajan V, Ramachandiran I, Massey W, Jain R, Banerjee R, Horak A, et al.
Elife
. 2024 Apr;
12.
PMID: 38648183
Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 gene and advanced liver diseases. Specifically, the common MBOAT7 variant (rs641738) associated with reduced...
6.
Taiwo M, Huang E, Pathak V, Bellar A, Welch N, Dasarathy J, et al.
JCI Insight
. 2024 Apr;
9(9).
PMID: 38573776
Diagnostic challenges continue to impede development of effective therapies for successful management of alcohol-associated hepatitis (AH), creating an unmet need to identify noninvasive biomarkers for AH. In murine models, complement...
7.
Mrdjen M, Huang E, Pathak V, Bellar A, Welch N, Dasarathy J, et al.
Hepatol Commun
. 2023 Oct;
7(11).
PMID: 37820283
Background: Chronic alcohol consumption impairs gut barrier function and perturbs the gut microbiome. Although shifts in bacterial communities in patients with alcohol-associated liver disease (ALD) have been characterized, less is...
8.
Varadharajan V, Ramachandiran L, Massey W, Jain R, Banerjee R, Horak A, et al.
bioRxiv
. 2023 Oct;
PMID: 37808828
Several recent genome-wide association studies (GWAS) have identified single nucleotide polymorphism (SNPs) near the gene encoding membrane-bound -acyltransferase 7 ( ) that is associated with advanced liver diseases. In fact,...
9.
Kim A, Ortega-Ribera M, McMullen M, Bellar A, Taiwo M, Pathak V, et al.
iScience
. 2023 Jun;
26(7):107133.
PMID: 37361874
Alcohol abuse causes increased susceptibility to respiratory syndromes like bacterial pneumonia and viral infections like SARS-CoV-2. Heavy drinkers (HD) are at higher risk of severe COVID-19 if they are also...
10.
Bellar A, Welch N, Dasarathy J, Attaway A, Musich R, Kumar A, et al.
Clin Transl Med
. 2023 May;
13(5):e1276.
PMID: 37228227
Background: Patients with acute alcohol-associated hepatitis (AH) have immune dysfunction. Mitochondrial function is critical for immune cell responses and regulates senescence. Clinical translational studies using complementary bioinformatics-experimental validation of mitochondrial...