V Z Slepak
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Explore the profile of V Z Slepak including associated specialties, affiliations and a list of published articles.
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27
Citations
573
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Recent Articles
1.
Grabowska D, Jayaraman M, Kaltenbronn K, Sandiford S, Wang Q, Jenkins S, et al.
Neuroscience
. 2008 Feb;
151(4):969-82.
PMID: 18248908
Members of the regulator of G protein signaling 7 (RGS7) (R7) family and Gbeta5 form obligate heterodimers that are expressed predominantly in the nervous system. R7-Gbeta5 heterodimers are GTPase-activating proteins...
2.
Balasubramanian N, Levay K, Faurobert E, Slepak V
Biochemistry
. 2001 Oct;
40(42):12619-27.
PMID: 11601986
In vertebrate photoreceptors, photoexcited rhodopsin interacts with the G protein transducin, causing it to bind GTP and stimulate the enzyme cGMP phosphodiesterase. The rapid termination of the active state of...
3.
Bera A, Zveig D, Peleg S, Witherow D, Slepak V, Dascal N
FEBS Lett
. 2001 Mar;
492(1-2):20-8.
PMID: 11248230
Regulators of G protein signaling RGS4 and RGS7 accelerate the kinetics of K(+) channels (GIRKs) in the Xenopus oocyte system. Here, via quantitative analysis of RGS expression, we reveal biphasic...
4.
Witherow D, Wang Q, Levay K, Cabrera J, Chen J, Willars G, et al.
J Biol Chem
. 2000 Jun;
275(32):24872-80.
PMID: 10840031
A novel protein class, termed regulators of G protein signaling (RGS), negatively regulates G protein pathways through a direct interaction with Galpha subunits and stimulation of GTP hydrolysis. An RGS...
5.
6.
Slepak V
J Mol Recognit
. 2000 Feb;
13(1):20-6.
PMID: 10679893
Hundreds of extracellular stimuli are received by cells via the pathways consisting of three basic components: cell-surface receptors, heterotrimeric G proteins, and intracellular effector enzymes or ion channels. A number...
7.
Levay K, Cabrera J, Satpaev D, Slepak V
Proc Natl Acad Sci U S A
. 1999 Mar;
96(5):2503-7.
PMID: 10051672
The G protein beta subunit Gbeta5 deviates significantly from the other four members of Gbeta-subunit family in amino acid sequence and subcellular localization. To detect the protein targets of Gbeta5...
8.
Craft C, Xu J, Slepak V, Zhu X, Brown B, Lolley R
Biochemistry
. 1998 Dec;
37(45):15758-72.
PMID: 9843381
In this study, we identify new isoforms of the retinal phosducin and investigate the expression of the phosducin family, showing that an isoform, PhLP1, has sequence homology with Phd and...
9.
Levay K, Satpaev D, Pronin A, Benovic J, Slepak V
Biochemistry
. 1998 Sep;
37(39):13650-9.
PMID: 9753452
Inhibition of G protein-coupled receptor kinases (GRKs) by Ca2+-binding proteins has recently emerged as a general mechanism of GRK regulation. While GRK1 (rhodopsin kinase) is inhibited by the photoreceptor-specific Ca2+-binding...
10.
Cabrera J, de Freitas F, Satpaev D, Slepak V
Biochem Biophys Res Commun
. 1998 Sep;
249(3):898-902.
PMID: 9731233
The G protein beta subunit G beta 5 deviates significantly from the four other members of the G beta family in amino acid sequence, unique expression pattern (only in the...