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V Saudek

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Articles 44
Citations 1367
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Recent Articles
1.
Fejzo M, Rocha N, Cimino I, Lockhart S, Petry C, Kay R, et al.
Nature . 2023 Dec; 625(7996):760-767. PMID: 38092039
GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but a full mechanistic understanding...
2.
Fejzo M, Rocha N, Cimino I, Lockhart S, Petry C, Kay R, et al.
bioRxiv . 2023 Jul; PMID: 37398065
Human pregnancy is frequently accompanied by nausea and vomiting that may become severe and life-threatening, as in hyperemesis gravidarum (HG), the cause of which is unknown. Growth Differentiation Factor-15 (GDF15),...
3.
Kralik L, Flachsova E, Hansikova H, Saudek V, Zeman J, Martasek P
Folia Biol (Praha) . 2018 Apr; 63(5-6):165-173. PMID: 29687769
Menkes disease is a severe X-linked recessive disorder caused by a defect in the ATP7A gene, which encodes a membrane copper-transporting ATPase. Deficient activity of the ATP7A protein results in...
4.
Kassak F, Hana V, Saudek V, Kostrouchova M
Folia Biol (Praha) . 2017 May; 63(2):60-66. PMID: 28557707
Production of thyroid hormone is precisely regulated in a negative feed-back mechanism that depends critically on thyroid hormone receptor β (TRβ). This mechanism decreases production of thyrotropin- releasing hormone (TRH)...
5.
Farrag M, Mikula I, Richard E, Saudek V, de Verneuil H, Martasek P
Folia Biol (Praha) . 2016 Jan; 61(6):219-26. PMID: 26789143
Porphyrias are metabolic disorders resulting from mutations in haem biosynthetic pathway genes. Hepatoerythropoietic porphyria (HEP) is a rare type of porphyria caused by the deficiency of the fifth enzyme (uroporphyrinogen...
6.
Zima V, Sebkova K, Simeckova K, Dvorak T, Saudek V, Kostrouchova M
Folia Biol (Praha) . 2015 Dec; 61(5):168-77. PMID: 26667573
The prorenin receptor (ATP6AP2) is a multifunctional transmembrane protein; it is a constituent of proton-translocating V-ATPase, a non-proteolytic activator of renin and an adaptor in the Wnt/β-catenin pathway. Here, we...
7.
Kozusko K, Tsang V, Bottomley W, Cho Y, Gandotra S, Mimmack M, et al.
Diabetes . 2014 Aug; 64(1):299-310. PMID: 25114292
Perilipin 1 is a lipid droplet coat protein predominantly expressed in adipocytes, where it inhibits basal and facilitates stimulated lipolysis. Loss-of-function mutations in the PLIN1 gene were recently reported in...
8.
Raska O, Kostrouchova V, Behensky F, Yilma P, Saudek V, Kostrouch Z, et al.
Folia Biol (Praha) . 2012 Jan; 57(6):223-31. PMID: 22264716
Nuclear receptors (NRs), or nuclear hormone receptors (NHRs), are transcription factors that regulate development and metabolism of most if not all animal species. Their regulatory networks include conserved mechanisms that...
9.
Bortmann P, Hoflack J, Pelton J, Saudek V
Neurochem Int . 2010 May; 18(4):491-6. PMID: 20504731
Endothelin-3 dissolved in 10% aqueous acetic acid was studied by nuclear magnetic resonance spectroscopy. A total of 363 distances (143 intra-residue, 108 sequential and 112 long range) was compiled from...
10.
Flachsova E, Verma I, Ulbrichova D, Saxena R, Zeman J, Saudek V, et al.
Folia Biol (Praha) . 2007 Dec; 53(6):194-201. PMID: 18070416
Based on Internet search, we were contacted by a 50-year-old man suffering from severe abdominal pain. Acute hepatic porphyria was considered from positive Watson-Schwartz test. He, not being a health...