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V Saudek

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Articles 44
Citations 1367
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Recent Articles
11.
George S, Johansen A, Soos M, MORTENSEN H, Gammeltoft S, Saudek V, et al.
Endocrinology . 2003 Jan; 144(2):631-7. PMID: 12538626
An infant with Donohue's syndrome (leprechaunism) was found to be homozygous for an in-frame trinucleotide deletion within the insulin receptor gene resulting in the deletion of valine 335. When transiently...
12.
Sich C, Improta S, Cowley D, Guenet C, Merly J, Teufel M, et al.
Eur J Biochem . 2000 Aug; 267(17):5342-55. PMID: 10951192
The structure of a recently reported neurotrophic ligand, 3-(3-pyridyl)-1-propyl(2S)-1-(3,3-dimethyl-1, 2-dioxopentyl)-2-pyrrolidinecarboxylate, in complex with FKBP12 was determined using heteronuclear NMR spectroscopy. The inhibitor exhibits a binding mode analogous to that observed...
13.
Fraternali F, Do Q, Doan B, Atkinson R, Palmas P, SKLENAR V, et al.
Proteins . 1998 Mar; 30(3):264-74. PMID: 9517542
The structure of two selective inhibitors, Ac-Tyr-Ile-Arg-Ile-Pro-NH2 and Ac-(4-Amino-Phe)-(Cyclohexyl-Gly)-Arg-NH2, in the active site of the blood clotting enzyme factor Xa was determined by using transferred nuclear Overhauser effect nuclear magnetic...
14.
Saudek V, Vincendon P, Do Q, Atkinson R, SKLENAR V, Pelton P, et al.
Eur J Biochem . 1996 Aug; 240(1):288-91. PMID: 8925839
The interaction of Li+ with myo-inositol monophosphatase was studied by 7Li-NMR spectroscopy. Li+ binding to the enzyme induces a downfield shift and broadening of the 7Li-NMR signal. Changes of the...
15.
Atkinson R, Saudek V, Pelton J
Int J Pept Protein Res . 1994 Jun; 43(6):563-72. PMID: 7928087
The structure of the disintegrin echistatin has been determined by 1H NMR, distance geometry calculations and restrained molecular dynamics simulations. The structure has been refined from the preliminary distance geometry...
16.
Huggins J, Ganzhorn A, Saudek V, Pelton J, Atkinson R
Eur J Biochem . 1994 Apr; 221(1):581-93. PMID: 8168546
The structure of cGMP-dependent protein kinase I alpha-(546-576)-peptide amide (peptide-546) and its effects on cGMP-dependent protein kinase I alpha (G-kinase) have been studied. By primary sequence analysis and analogy to...
17.
Wright P, Saudek V, Owen T, Harbeson S, Bitonti A
Biochem J . 1993 Jul; 293 ( Pt 1):263-7. PMID: 7687129
Integrin binding to proteins often involves recognition of domains containing the arginine-glycine-aspartate (RGD) motif. Different binding affinities and specificities of the integrin-ligand protein interactions involve additional protein domains. The n.m.r....
18.
Piotto M, Saudek V, SKLENAR V
J Biomol NMR . 1992 Nov; 2(6):661-5. PMID: 1490109
A novel approach to tailored selective excitation for the measurement of NMR spectra in non-deuterated aqueous solutions (WATERGATE, WATER suppression by GrAdient-Tailored Excitation) is described. The gradient echo sequence, which...
19.
Cowley D, Hoflack J, Pelton J, Saudek V
Eur J Biochem . 1992 May; 205(3):1099-106. PMID: 1576993
The structure of porcine neuropeptide Y in 0.05 M CD3COOD/D2O was determined by nuclear magnetic resonance spectroscopy. Nuclear Overhauser spectra yielded 377 distances which define a helical segment formed by...
20.
Pastore A, Saudek V, Ramponi G, Williams R
J Mol Biol . 1992 Mar; 224(2):427-40. PMID: 1313885
We report here the complete determination of the solution structure of acylphosphatase, a small enzyme that catalyses the hydrolysis of organic acylphosphates, as determined by distance geometry methods based on...