V Sasisekharan
Overview
Explore the profile of V Sasisekharan including associated specialties, affiliations and a list of published articles.
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88
Citations
2761
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Recent Articles
1.
Raguram A, Sasisekharan V, Sasisekharan R
Trends Microbiol
. 2017 Jan;
25(6):438-446.
PMID: 28094093
Recent developments of rational strategies for the design of antiviral therapies, including monoclonal antibodies (mAbs), have naturally relied extensively on available viral structural information. As new strategies continue to be...
2.
Raman R, Tharakaraman K, Sasisekharan V, Sasisekharan R
Curr Opin Struct Biol
. 2016 Oct;
40:153-162.
PMID: 27792989
The surfaces of host cells and viruses are decorated by complex glycans, which play multifaceted roles in the dynamic interplay between the virus and the host including viral entry into...
3.
Robinson L, Tharakaraman K, Rowley K, Costa V, Chan K, Wong Y, et al.
Cell
. 2015 Jul;
162(3):493-504.
PMID: 26189681
Dengue is the most common vector-borne viral disease, causing nearly 400 million infections yearly. Currently there are no approved therapies. Antibody epitopes that elicit weak humoral responses may not be...
4.
Raman R, Tharakaraman K, Shriver Z, Jayaraman A, Sasisekharan V, Sasisekharan R
Trends Microbiol
. 2014 Aug;
22(11):632-41.
PMID: 25108746
Influenza A viruses are rapidly evolving pathogens with the potential for novel strains to emerge and result in pandemic outbreaks in humans. Some avian-adapted subtypes have acquired the ability to...
5.
Tharakaraman K, Jayaraman A, Raman R, Viswanathan K, Stebbins N, Johnson D, et al.
Cell
. 2013 Jun;
153(7):1486-93.
PMID: 23746830
The advent of H7N9 in early 2013 is of concern for a number of reasons, including its capability to infect humans, the lack of clarity in the etiology of infection,...
6.
Structural determinants for naturally evolving H5N1 hemagglutinin to switch its receptor specificity
Tharakaraman K, Raman R, Viswanathan K, Stebbins N, Jayaraman A, Krishnan A, et al.
Cell
. 2013 Jun;
153(7):1475-85.
PMID: 23746829
Of the factors governing human-to-human transmission of the highly pathogenic avian-adapted H5N1 virus, the most critical is the acquisition of mutations on the viral hemagglutinin (HA) to "quantitatively switch" its...
7.
Tharakaraman K, Robinson L, Hatas A, Chen Y, Siyue L, Raguram S, et al.
Proc Natl Acad Sci U S A
. 2013 Apr;
110(17):E1555-64.
PMID: 23569282
Affinity improvement of proteins, including antibodies, by computational chemistry broadly relies on physics-based energy functions coupled with refinement. However, achieving significant enhancement of binding affinity (>10-fold) remains a challenging exercise,...
8.
9.
Soundararajan V, Zheng S, Patel N, Warnock K, Raman R, Wilson I, et al.
Sci Rep
. 2012 Feb;
1:200.
PMID: 22355715
Influenza viral passaging through pre-vaccinated mice shows that emergent antigenic site mutations on the viral hemagglutinin (HA) impact host receptor-binding affinity and, therefore, the evolution of fitter influenza strains. To...
10.
Viswanathan K, Chandrasekaran A, Srinivasan A, Raman R, Sasisekharan V, Sasisekharan R
Glycoconj J
. 2010 Aug;
27(6):561-70.
PMID: 20734133
Influenza A viruses, members of the Orthomyxoviridae family, are responsible for annual seasonal influenza epidemics and occasional global pandemics. The binding of viral coat glycoprotein hemagglutinin (HA) to sialylated glycan...