V R Arruda
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Explore the profile of V R Arruda including associated specialties, affiliations and a list of published articles.
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76
Citations
898
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Recent Articles
1.
Nguyen G, George L, Siner J, Davidson R, Zander C, Zheng X, et al.
J Thromb Haemost
. 2016 Oct;
15(1):110-121.
PMID: 27749002
Summary: Background The major challenge for developing gene-based therapies for hemophilia A is that human factor VIII (hFVIII) has intrinsic properties that result in inefficient biosynthesis. During intracellular processing, hFVIII...
2.
Arruda V, Annichino-Bizzacchi J, Antunes S, Costa F
Haemophilia
. 2016 May;
2(1):51-3.
PMID: 27213907
The clinical severity of haemophilia is usually related to residual clotting factor activity. Reports of factor V deficiency or protein C have been described in haemophilic patients and both are...
3.
Arruda V, Samelson-Jones B
J Thromb Haemost
. 2016 Apr;
14(6):1121-34.
PMID: 27061380
The development of inhibitors, i.e. neutralizing alloantibodies against factor (F) VIII or FIX, is the most significant complication of protein replacement therapy for patients with hemophilia, and is associated with...
4.
Greene T, Lyde R, Bailey S, Lambert M, Zhai L, Sabatino D, et al.
J Thromb Haemost
. 2014 Oct;
12(12):2102-12.
PMID: 25287191
Background: Ectopically expressed B-domainless factor VIII in megakaryocytes is stored in α-granules, is effective in a number of murine hemostatic models, and is protected from circulating inhibitors. However, this platelet...
5.
An engineered U1 small nuclear RNA rescues splicing defective coagulation F7 gene expression in mice
Balestra D, Faella A, Margaritis P, Cavallari N, Pagani F, Bernardi F, et al.
J Thromb Haemost
. 2014 Apr;
12(2):177-85.
PMID: 24738135
Background: The ability of the spliceosomal small nuclear RNA U1 (U1snRNA) to rescue pre-mRNA splicing impaired by mutations makes it an attractive therapeutic molecule. Coagulation factor deficiencies due to splicing...
6.
Fabri D, De Paula E, Costa D, Annichino-Bizzacchi J, Arruda V
J Thromb Haemost
. 2011 Jun;
9(8):1556-61.
PMID: 21692978
Background: Cardiovascular diseases in aging people with hemophilia (PWH) represent a growing concern. The underlying hypocoagulability probably provides a protective effect against acute thrombus formation, but the limited data available...
7.
Nichols T, Raymer R, Franck H, Merricks E, Bellinger D, Defriess N, et al.
Haemophilia
. 2010 Jul;
16 Suppl 3:19-23.
PMID: 20586797
Dogs with haemophilia A or haemophilia B exhibit spontaneous bleeding comparable with the spontaneous bleeding phenotype that occurs in humans with severe haemophilia. The phenotypic and genotypic characteristics of haemophilic...
8.
Tai S, Herzog R, Margaritis P, Arruda V, Chu K, Golden J, et al.
J Thromb Haemost
. 2007 Nov;
6(2):339-45.
PMID: 18036190
Background: Activated factor X (FXa) is a vitamin K-dependent serine protease that plays a pivotal role in blood coagulation by converting prothrombin to thrombin. There are no reports of humans...
9.
10.
Assis A, Costa F, Arruda V, Annichino-Bizzacchi J, Bertuzzo C
J Hum Genet
. 2007 Jan;
52(3):237-243.
PMID: 17219009
Hereditary hemorrhagic telangiectasia (HHT) or Osler-Rendu-Weber disease is a systemic fibrovascular dysplasia with an autosomal dominant inheritance pattern. Mutations in two genes, endoglin and ALK-1, are known to cause HHT,...