V P Sukhatme
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Explore the profile of V P Sukhatme including associated specialties, affiliations and a list of published articles.
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132
Citations
5181
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Recent Articles
11.
Hari D, Beckett M, Sukhatme V, Dhanabal M, Nodzenski E, Lu H, et al.
Mol Cell Biol Res Commun
. 2000 Aug;
3(5):277-82.
PMID: 10964751
Angiostatin is an inhibitor of tumor angiogenesis that induces regression of experimental tumors and enhances the antitumor effects of radiation therapy. We report that the cytotoxic effects of angiostatin are...
12.
Kalluri R, Sukhatme V
Curr Opin Nephrol Hypertens
. 2000 Aug;
9(4):413-8.
PMID: 10926178
Research during the past few years has contributed vastly to a better understanding of fibrosis and angiogenesis. Although studies to understand the molecular processes associated with fibrosis and angiogenesis were...
13.
Colorado P, Torre A, Kamphaus G, Maeshima Y, Hopfer H, Takahashi K, et al.
Cancer Res
. 2000 May;
60(9):2520-6.
PMID: 10811134
Vascular basement membrane is an important structural component of blood vessels and has been shown to interact with and modulate vascular endothelial behavior during angiogenesis. During the inductive phase of...
14.
Yokoyama Y, Dhanabal M, Griffioen A, Sukhatme V, Ramakrishnan S
Cancer Res
. 2000 Apr;
60(8):2190-6.
PMID: 10786683
Ovarian cancer is the leading cause of fatality among gynecological malignancies. Ovarian cancer growth is angiogenesis-dependent, and an increased production of angiogenic growth factors such as vascular endothelial growth factor...
15.
McDONALD G, Zhu G, Li Y, Kovesdi I, Wickham T, Sukhatme V
J Gene Med
. 2000 Mar;
1(2):103-10.
PMID: 10738574
Background: The alpha v integrin is present in vascular endothelium, including that of the kidney. It is also upregulated in the presence of inflammatory cytokines and in some neoplasms. In...
16.
Sukhatme V
Semin Nephrol
. 2000 Jan;
20(1):87-91.
PMID: 10651222
Physician-scientists play a key role in bringing basic science advances anticipated in the new millennium to the bedside. However, the existence of such individuals is in jeopardy, the reasons for...
17.
Kamphaus G, Colorado P, Panka D, Hopfer H, Ramchandran R, Torre A, et al.
J Biol Chem
. 2000 Jan;
275(2):1209-15.
PMID: 10625665
We isolated and identified an endogenous 24-kDa human basement membrane-derived inhibitor of angiogenesis and tumor growth, termed canstatin. Canstatin, a fragment of the alpha2 chain of type IV collagen, was...
18.
Cohen H, Zhou M, WELSH A, Zarghamee S, Scholz H, Mukhopadhyay D, et al.
Biochem Biophys Res Commun
. 1999 Dec;
266(1):43-50.
PMID: 10581162
VHL is the causative gene for both von Hippel-Lindau (VHL) disease and sporadic clear-cell renal cancer. We showed earlier that VHL downregulates vascular endothelial growth factor transcription by directly binding...
19.
Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, et al.
Proc Natl Acad Sci U S A
. 1999 May;
96(11):6371-6.
PMID: 10339594
Regulators of G protein signaling (RGS) proteins accelerate the intrinsic GTPase activity of certain Galpha subunits and thereby modulate a number of G protein-dependent signaling cascades. Currently, little is known...
20.
Lu H, Dhanabal M, Volk R, Waterman M, Ramchandran R, Knebelmann B, et al.
Biochem Biophys Res Commun
. 1999 May;
258(3):668-73.
PMID: 10329443
Angiostatin which contains the first four kringle domains of plasminogen has been documented to be a potent inhibitor of angiogenesis. More recently, another kringle structure within plasminogen but outside angiostatin,...