V Nurcombe
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Explore the profile of V Nurcombe including associated specialties, affiliations and a list of published articles.
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58
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1003
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Recent Articles
1.
Le B, Too J, Tan T, Smith R, Nurcombe V, Cool S, et al.
Eur Cell Mater
. 2021 Aug;
42:139-153.
PMID: 34464450
Periodontitis is the most common inflammatory disease that leads to periodontal defects and tooth loss. Regeneration of alveolar bone and soft tissue in periodontal defects is highly desirable but remains...
2.
Lim Z, Rai B, Tan T, Ramruttun A, Hui J, Nurcombe V, et al.
Bone Joint Res
. 2019 Apr;
8(3):107-117.
PMID: 30997036
Objectives: Long bone defects often require surgical intervention for functional restoration. The 'gold standard' treatment is autologous bone graft (ABG), usually from the patient's iliac crest. However, autograft is plagued...
3.
Rai B, Chatterjea A, Lim Z, Tan T, Sawyer A, Hosaka Y, et al.
Acta Biomater
. 2015 Sep;
28:193-204.
PMID: 26384700
Statement Of Significance: Synthetic bone grafts and demineralized bone matrices are gaining prominence as alternatives to autologous and allogeneic bone grafts and are frequently administered in granular form, necessitating their...
4.
Murali S, Rai B, Dombrowski C, Lee J, Lim Z, Bramono D, et al.
Biomaterials
. 2013 May;
34(22):5594-605.
PMID: 23632323
Bone morphogenetic protein (BMP)-2 is a potent bone healing compound produced at sites of bone trauma. Here we present a therapeutic strategy to harness the activity of endogenously produced BMP-2...
5.
Kumarasuriyar A, Lee I, Nurcombe V, Cool S
J Cell Physiol
. 2009 Jan;
219(3):572-83.
PMID: 19142873
Glycosaminoglycan (GAG) sugars are largely responsible for the bioactivity of the proteoglycan proteins they decorate, and are particularly important for mediating the processes of cell attachment and growth factor signaling....
6.
Kumarasuriyar A, Murali S, Nurcombe V, Cool S
J Cell Physiol
. 2008 Nov;
218(3):501-11.
PMID: 18988189
Osteogenic differentiation is coordinated by the exposure of cells to temporal changes in a combination of growth factors and elements within the extracellular matrix (ECM). Many of the key proteins...
7.
Cool S, Kenny B, Wu A, Nurcombe V, Trau M, Cassady A, et al.
J Biomed Mater Res A
. 2007 Feb;
82(3):599-610.
PMID: 17315229
The efficacy of composite materials for bone tissue engineering is dependent on the materials' ability to support bone regeneration whilst inducing a minimal inflammatory response. In this study we examined...
8.
Song S, Hutmacher D, Nurcombe V, Cool S
Gene
. 2006 Jul;
379:92-100.
PMID: 16842937
Proteoglycans found in the bone extracellular matrix and on the cell surface can complex with HBGFs such as the FGFs, TGFs and BMPs which are known to play key roles...
9.
Kumarasuriyar A, Jackson R, Grondahl L, Trau M, Nurcombe V, Cool S
Tissue Eng
. 2005 Sep;
11(7-8):1281-95.
PMID: 16144464
Studies have demonstrated that polymeric biomaterials have the potential to support osteoblast growth and development for bone tissue repair. Poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV), a bioabsorbable, biocompatible polyhydroxy acid polymer, is an excellent...
10.
Small D, Clarris H, Williamson T, Reed G, Key B, Mok S, et al.
J Alzheimers Dis
. 2002 Sep;
1(4-5):275-85.
PMID: 12214125
Many studies have shown that breakdown of the amyloid protein precursor (APP) to produce the amyloid protein is an important step in the pathogenic mechanism which causes Alzheimer's disease (AD)....