V Marcel
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Explore the profile of V Marcel including associated specialties, affiliations and a list of published articles.
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20
Citations
627
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Recent Articles
1.
Marcel V, Catez F, Diaz J
Oncogene
. 2015 Mar;
34(44):5513-23.
PMID: 25728674
A growing body of evidences indicate that deregulation of translation contributes to tumourigenesis. In tumours, alterations of translational control of specific mRNAs encoding oncogenes or tumour suppressors have been extensively...
2.
Marcel V, Fernandes K, Terrier O, Lane D, Bourdon J
Cell Death Differ
. 2014 Jun;
21(9):1377-87.
PMID: 24926616
In addition to the tumor suppressor p53 protein, also termed p53α, the TP53 gene produces p53β and p53γ through alternative splicing of exons 9β and 9γ located within TP53 intron...
3.
Sagne C, Marcel V, Amadou A, Hainaut P, Olivier M, Hall J
Cell Death Dis
. 2013 Feb;
4:e492.
PMID: 23412385
We have performed a meta-analysis of cancer risk associated with the rs17878362 polymorphism of the TP53 suppressor gene (PIN3, (polymorphism in intron 3), 16 bp sequence insertion/duplication in intron 3),...
4.
Marcel V, Petit I, Murray-Zmijewski F, Goullet de Rugy T, Fernandes K, Meuray V, et al.
Cell Death Differ
. 2011 Nov;
19(5):816-26.
PMID: 22075982
In response to stress, p53 binds and transactivates the internal TP53 promoter, thus regulating the expression of its own isoform, Δ133p53α. Here, we report that, in addition to p53, at...
5.
Marcel V, Dichtel-Danjoy M, Sagne C, Hafsi H, Ma D, Ortiz-Cuaran S, et al.
Cell Death Differ
. 2011 Sep;
18(12):1815-24.
PMID: 21941372
The TP53 tumour-suppressor gene is expressed as several protein isoforms generated by different mechanisms, including use of alternative promoters, splicing sites and translational initiation sites, that are conserved through evolution...
6.
Marcel V, Olivier M, Mollereau B, Hainaut P, Bourdon J
Cell Death Differ
. 2010 Dec;
18(3):563-4.
PMID: 21151028
No abstract available.
7.
Goldstein I, Marcel V, Olivier M, Oren M, Rotter V, Hainaut P
Cancer Gene Ther
. 2010 Oct;
18(1):2-11.
PMID: 20966976
Three decades of p53 research have led to many advances in understanding the basic biology of normal and cancer cells. Nonetheless, the detailed functions of p53 in normal cells, and...
8.
Marcel V, Vijayakumar V, Fernandez-Cuesta L, Hafsi H, Sagne C, Hautefeuille A, et al.
Oncogene
. 2010 Mar;
29(18):2691-700.
PMID: 20190805
The tumor suppressor p53 protein is activated by genotoxic stress and regulates genes involved in senescence, apoptosis and cell-cycle arrest. Nine p53 isoforms have been described that may modulate suppressive...
9.
Marcel V, Palmero E, Falagan-Lotsch P, Martel-Planche G, Ashton-Prolla P, Olivier M, et al.
J Med Genet
. 2009 Jun;
46(11):766-72.
PMID: 19542078
Background: Li-Fraumeni and Li-Fraumeni-like syndromes (LFS/LFL), characterised by the development of multiple early onset cancers with heterogeneous tumour patterns, are associated with germline TP53 mutations. Polymorphisms in the TP53 pathway...
10.
Marcel V, Hainaut P
Cell Mol Life Sci
. 2008 Oct;
66(3):391-406.
PMID: 18854945
For 25 years, the p53 tumor suppressor protein was considered the only protein expressed by the (TP53) gene. However, in several studies the existence of p53 alternative transcripts in mouse...