V Ashutosh Rao
Overview
Explore the profile of V Ashutosh Rao including associated specialties, affiliations and a list of published articles.
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Articles
63
Citations
6858
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Recent Articles
1.
Zhou L, Ortega-Rodriguez U, Flores M, Matsumoto Y, Bettinger J, Wu W, et al.
Nat Commun
. 2025 Feb;
16(1):1960.
PMID: 40000644
Mucin-type O-glycans on glycoproteins are pivotal for biology and impact the quality of biotherapeutics. Furthermore, glycans on host cells serve as ligands for lectins/adhesins on bacteria for bacterium-host interactions in...
2.
Pritts J, Falkowski V, Biel T, Embretsen M, Aryal B, Tillotson J, et al.
J Pharm Sci
. 2025 Jan;
114(2):1495-1503.
PMID: 39778740
Post translational modifications (PTMs) of proteins play an integral role in maintaining the overall structure and function of proteins including their proper folding, binding, and potency. However, not all PTMs...
3.
Biel T, Faison T, Matthews A, Ortega-Rodriguez U, Falkowski V, Meek E, et al.
Bioeng Transl Med
. 2024 Nov;
9(5):e10666.
PMID: 39553427
Organophosphate (OP) toxicants remain an active threat to public health and to warfighters in the military. Current countermeasures require near immediate administration following OP exposure and are reported to have...
4.
Ortega-Rodriguez U, Bettinger J, Zou G, Falkowski V, Lehtimaki M, Matthews A, et al.
Cell Rep Methods
. 2024 Aug;
4(8):100834.
PMID: 39116882
Glycosylation is generally characterized and controlled as a critical quality attribute for therapeutic glycoproteins because glycans can impact protein drug-product efficacy, half-life, stability, and safety. Analytical procedures to characterize N-glycans...
5.
Aryal B, Lehtimaki M, Rao V
Pharm Res
. 2024 May;
41(6):1217-1232.
PMID: 38740663
Purpose: Polysorbates are the most commonly used surfactants in formulations to stabilize therapeutic proteins against interfacial stresses. Polysorbates can undergo oxidative or enzyme-mediated hydrolytic degradation to produce free fatty acids...
6.
Bergonzo C, Aryal B, Rao V
J Mol Graph Model
. 2023 Aug;
124:108576.
PMID: 37536231
The dosing and efficacy of chemotherapeutic drugs can be limited by toxicity caused by off-pathway reactions. One hypothesis for how such toxicity arises is via metal-catalyzed oxidative damage of cardiac...
7.
Scott E, Baines A, Gong Y, Moore Jr R, Pamuk G, Saber H, et al.
Nat Rev Drug Discov
. 2023 Jun;
22(8):625-640.
PMID: 37344568
The cancer treatment landscape has changed dramatically since the turn of the century, resulting in substantial improvements in outcomes for patients. This Review summarizes trends in the approval of oncology...
8.
Garige M, Ghosh S, Roelofs B, Rao V, Sourbier C
Methods Protoc
. 2023 Apr;
6(2).
PMID: 37104015
Insulin is a hormone produced by β-cells of the pancreas and controls the amount of sugar in the blood. Since its discovery over 100 years ago, insulin has been used...
9.
Kim J, Pritts J, Ngo M, Estoll C, Rao V
Pharm Res
. 2023 Apr;
40(6):1491-1505.
PMID: 37022633
Purpose: Inherent structural and functional properties of biotechnology-derived therapeutic biologics make them susceptible to light- and temperature-induced degradation and consequently can influence their quality. Photosensitivity of therapeutic proteins continues to...
10.
Biel T, Petrovskaya S, Mascia F, Ju T, Fashoyin-Aje L, Herremans K, et al.
PLoS One
. 2023 Feb;
18(2):e0281182.
PMID: 36812168
In pancreatic cancer clinical trials, Black patients are under-represented while having higher morbidity and mortality rates as compared to other racial groups. Multiple factors, including socioeconomic and lifestyle factors may...