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V Arango

Explore the profile of V Arango including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 62
Citations 1644
Followers 0
Related Specialties
Neurology
Psychiatry
Molecular Biology
Top 10 Co-Authors
J J Mann
M D Underwood
D J Reis
A J Dwork
D A Ruggiero
P Ernsberger
M J Bakalian
S A Kassir
P M Marzuk
Y Y Huang
Published In
Brain Res
Mol Psychiatry
Neuroscience
Neuropsychopharmacology
Transl Psychiatry
Affiliations
Soon will be listed here.
Recent Articles
1.
Region-specific alterations of A-to-I RNA editing of serotonin 2c receptor in the cortex of suicides with major depression
Weissmann D, van der Laan S, Underwood M, Salvetat N, Cavarec L, Vincent L, et al.
Transl Psychiatry . 2016 Aug; 6(8):e878. PMID: 27576167
Brain region-specific abnormalities in serotonergic transmission appear to underlie suicidal behavior. Alterations of RNA editing on the serotonin receptor 2C (HTR2C) pre-mRNA in the brain of suicides produce transcripts that...
2.
Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity
Pantazatos S, Huang Y, Rosoklija G, Dwork A, Arango V, Mann J
Mol Psychiatry . 2016 Aug; 22(5):760-773. PMID: 27528462
Brain gene expression profiling studies of suicide and depression using oligonucleotide microarrays have often failed to distinguish these two phenotypes. Moreover, next generation sequencing approaches are more accurate in quantifying...
3.
The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription
Donaldson Z, le Francois B, Santos T, Almli L, Boldrini M, Champagne F, et al.
Transl Psychiatry . 2016 Mar; 6:e746. PMID: 26926882
The G/C single-nucleotide polymorphism in the serotonin 1a receptor promoter, rs6295, has previously been linked with depression, suicide and antidepressant responsiveness. In vitro studies suggest that rs6295 may have functional...
4.
Genetic neuropathology of obsessive psychiatric syndromes
Jaffe A, Deep-Soboslay A, Tao R, Hauptman D, Kaye W, Arango V, et al.
Transl Psychiatry . 2014 Sep; 4:e432. PMID: 25180571
Anorexia nervosa (AN), bulimia nervosa (BN) and obsessive-compulsive disorder (OCD) are complex psychiatric disorders with shared obsessive features, thought to arise from the interaction of multiple genes of small effect...
5.
Unaltered neuronal and glial counts in animal models of magnetic seizure therapy and electroconvulsive therapy
Dwork A, Christensen J, Larsen K, Scalia J, Underwood M, Arango V, et al.
Neuroscience . 2009 Sep; 164(4):1557-64. PMID: 19782728
Anatomical evidence of brain damage from electroconvulsive therapy (ECT) is lacking; but there are no modern stereological studies in primates documenting its safety. Magnetic seizure therapy (MST) is under development...
6.
Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression
Haghighi F, Bach-Mizrachi H, Huang Y, Arango V, Shi S, Dwork A, et al.
Mol Psychiatry . 2008 Jan; 13(8):813-20. PMID: 18180764
Impaired brain serotonin neurotransmission is a potential component of the diathesis of major depression. Tryptophan hydroxylase-2 (TPH2), is the rate limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in...
7.
Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides
Bach-Mizrachi H, Underwood M, Tin A, Ellis S, Mann J, Arango V
Mol Psychiatry . 2008 Jan; 13(5):507-13, 465. PMID: 18180753
Deficient levels of serotonin are associated with suicide and depression. Paradoxically, in the dorsal raphe nucleus (DRN) there are more serotonin neurons and more neuronal tryptophan hydroxylase-2 (TPH2) expression postmortem...
8.
Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims
Hungund B, Vinod K, Kassir S, Basavarajappa B, Yalamanchili R, Cooper T, et al.
Mol Psychiatry . 2004 Feb; 9(2):184-90. PMID: 14966476
Endogenous and exogenous cannabinoids (CBs) acting through the CB(1) receptors have been implicated in the regulation of several behavioral and neuroendocrine functions. Modulation of endocannabinoidergic system by ethanol in mouse...
9.
Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins
Flynn S, Lang D, MacKay A, Goghari V, Vavasour I, Whittall K, et al.
Mol Psychiatry . 2003 Aug; 8(9):811-20. PMID: 12931208
Schizophrenia unfolds during the late period of brain maturation, while myelination is still continuing. In the present study, we used MRI and T2 relaxation analysis to measure the myelin water...
10.
Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness
Sawada K, Young C, Barr A, Longworth K, Takahashi S, Arango V, et al.
Mol Psychiatry . 2002 Jun; 7(5):484-92. PMID: 12082566
Recent imaging and postmortem studies suggest that impaired connectivity is involved in the pathophysiology of schizophrenia and major affective disorders. We investigated the presynaptic proteins complexin (Cx) I and Cx...