Utkarsh Tripathi
Overview
Explore the profile of Utkarsh Tripathi including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
413
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Recent Articles
11.
Tripathi U, Mizrahi L, Alda M, Falkovich G, Stern S
Bipolar Disord
. 2022 Dec;
25(2):110-127.
PMID: 36479788
Aim: Bipolar disorder (BD) is a mood disorder with a high morbidity and death rate. Lithium (Li), a prominent mood stabilizer, is often used as a first-line treatment. However, clinical...
12.
Zhu Y, Langhi Prata L, Wissler Gerdes E, Espindola Netto J, Pirtskhalava T, Giorgadze N, et al.
EBioMedicine
. 2022 Mar;
77:103912.
PMID: 35292270
Background: α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious changes with ageing and disease. Declines in α-Klotho play a role in the pathophysiology of multiple diseases and...
13.
Tripathi U, Chaib S, Wissler Gerdes E, Hogan K, Zhu Y
EBioMedicine
. 2021 Nov;
74:103693.
PMID: 34768086
No abstract available.
14.
Tripathi U, Nchioua R, Langhi Prata L, Zhu Y, Wissler Gerdes E, Giorgadze N, et al.
Aging (Albany NY)
. 2021 Sep;
13(18):21838-21854.
PMID: 34531331
Senescent cells, which arise due to damage-associated signals, are apoptosis-resistant and can express a pro-inflammatory, tissue-destructive senescence-associated secretory phenotype (SASP). We recently reported that a component of the severe acute...
15.
Tripathi U, Misra A, Tchkonia T, Kirkland J
Mech Ageing Dev
. 2021 Aug;
198:111548.
PMID: 34352325
Cellular senescence, first observed and defined through cell culture studies, is a cell fate associated with essentially permanent cell cycle arrest and that can be triggered by a variety of...
16.
Camell C, Yousefzadeh M, Zhu Y, Langhi Prata L, Huggins M, Pierson M, et al.
Science
. 2021 Jun;
373(6552).
PMID: 34103349
The COVID-19 pandemic has revealed the pronounced vulnerability of the elderly and chronically ill to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced morbidity and mortality. Cellular senescence contributes to inflammation,...
17.
Gao H, Tripathi U, Trushin S, Okromelidze L, Pichurin N, Wei L, et al.
Mitochondrion
. 2021 Feb;
58:83-94.
PMID: 33610756
Novel therapeutic strategies for Alzheimer's disease (AD) are of the greatest priority given the consistent failure of recent clinical trials focused on Aβ or pTau. Earlier, we demonstrated that mild...
18.
Stojakovic A, Trushin S, Sheu A, Khalili L, Chang S, Li X, et al.
Commun Biol
. 2021 Jan;
4(1):61.
PMID: 33420340
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder without a cure. Here we show that mitochondrial respiratory chain complex I is an important small molecule druggable target in AD. Partial...
19.
Wissler Gerdes E, Zhu Y, Weigand B, Tripathi U, Burns T, Tchkonia T, et al.
Int Rev Neurobiol
. 2020 Aug;
155:203-234.
PMID: 32854855
Aging is the major predictor for developing multiple neurodegenerative diseases, including Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells, which can drive aging phenotypes, accumulate at etiological...
20.
Wettmarshausen J, Goh V, Huang K, Arduino D, Tripathi U, Leimpek A, et al.
Cell Rep
. 2018 Nov;
25(6):1425-1435.e7.
PMID: 30403999
The mitochondrial calcium uniporter is a highly selective ion channel composed of species- and tissue-specific subunits. However, the functional role of each component still remains unclear. Here, we establish a...