Ursula E Seidler
Overview
Explore the profile of Ursula E Seidler including associated specialties, affiliations and a list of published articles.
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11
Citations
103
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Recent Articles
1.
Seidler U
Front Pharmacol
. 2025 Feb;
15:1536864.
PMID: 39949394
SLC26A6, a member of the SLC26 family of multifunctional anion transporters, has been particularly enigmatic because of its multiple modes of transport, its expression in organs that are difficult to...
2.
Jiang M, Salari A, Stock C, Nikolovska K, Boedtkjer E, Amiri M, et al.
Am J Physiol Cell Physiol
. 2024 Apr;
326(6):C1625-C1636.
PMID: 38646790
NBCn1 (SLC4A7) is one of the two major Na-HCO cotransporters in the human colonic epithelium, expressed predominantly in the highly proliferating colonocytes at the cryptal base. Increased NBCn1 expression levels...
3.
Becker H, Seidler U
Pflugers Arch
. 2024 Feb;
476(4):593-610.
PMID: 38374228
The transport of bicarbonate across the enterocyte cell membrane regulates the intracellular as well as the luminal pH and is an essential part of directional fluid movement in the gut....
4.
Amiri M, Jiang M, Salari A, Xiu R, Alper S, Seidler U
Am J Physiol Cell Physiol
. 2024 Jan;
326(3):C829-C842.
PMID: 38223928
Loss of function mutations in the gene cause chloride-losing diarrhea in mice and humans. Although systemic adaptive changes have been documented in these patients and in the corresponding knockout mice,...
5.
Nikolovska K, Seidler U, Stock C
Front Physiol
. 2022 Jun;
13:899286.
PMID: 35665228
The five plasma membrane Na/H exchanger (NHE) isoforms in the gastrointestinal tract are characterized by distinct cellular localization, tissue distribution, inhibitor sensitivities, and physiological regulation. NHE1 (Slc9a1) is ubiquitously expressed...
6.
Kelly J, Al-Rammahi M, Daly K, Flanagan P, Urs A, Cohen M, et al.
Sci Rep
. 2022 Apr;
12(1):6593.
PMID: 35449374
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Defective CFTR leads to accumulation of dehydrated viscous mucus within the small intestine, luminal...
7.
Amiri M, Seidler U, Nikolovska K
Front Cell Dev Biol
. 2021 Feb;
9:618135.
PMID: 33553180
During the maturation of intestinal epithelial cells along the crypt/surface axis, a multitude of acid/base transporters are differentially expressed in their apical and basolateral membranes, enabling processes of electrolyte, macromolecule,...
8.
Tan Q, di Stefano G, Tan X, Renjie X, Romermann D, Talbot S, et al.
Br J Pharmacol
. 2020 Nov;
178(5):1018-1036.
PMID: 33179259
Background And Purpose: Constipation and intestinal obstructive episodes are major health problems in cystic fibrosis (CF) patients. Three FDA-approved drugs against constipation-prone irritable bowel syndrome were tested for their ability...
9.
Luo M, Yeruva S, Liu Y, Chodisetti G, Riederer B, Menon M, et al.
Front Physiol
. 2017 Feb;
8:61.
PMID: 28223944
The PDZ adaptor protein PDZK1 modulates the membrane expression and function of a variety of intestinal receptors and ion/nutrient transporters. Its expression is strongly decreased in inflamed intestinal mucosa of...
10.
Seidler U
Curr Opin Pharmacol
. 2013 Nov;
13(6):900-8.
PMID: 24280619
The concept of a protective alkaline gastric and duodenal mucus layer is a century old, yet it is amazing how much new information on HCO3(-) transport pathways has emerged recently,...