Uri Ben-David
Overview
Explore the profile of Uri Ben-David including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
66
Citations
4584
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Rendo V, Schubert M, Khuu N, Suarez Peredo Rodriguez M, Whyte D, Ling X, et al.
Nat Commun
. 2025 Jan;
16(1):1077.
PMID: 39870664
While the effect of amplification-induced oncogene expression in cancer is known, the impact of copy-number gains on "bystander" genes is less understood. We create a comprehensive map of dosage compensation...
2.
Zheng S, Raz L, Zhou L, Cohen-Sharir Y, Tian R, Ippolito M, et al.
EMBO Rep
. 2025 Jan;
26(4):1036-1061.
PMID: 39838194
Spindle assembly checkpoint (SAC) inhibitors are a recently developed class of drugs, which perturb chromosome segregation during cell division, induce chromosomal instability (CIN), and eventually lead to cell death. The...
3.
Haj M, Frey Y, Levon A, Maliah A, Ben-Yishay T, Slutsky R, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(2):e2419196122.
PMID: 39772747
Ataxia-telangiectasia (A-T) is a pleiotropic genome instability syndrome resulting from the loss of the homeostatic protein kinase ATM. The complex phenotype of A-T includes progressive cerebellar degeneration, immunodeficiency, gonadal atrophy,...
4.
Israeli Dangoor S, Khoury R, Salomon K, Pozzi S, Shahar S, Miari A, et al.
Brain
. 2024 Oct;
PMID: 39450648
Over the last two decades, the diagnosis and treatment of breast cancer patients have considerably improved. However, brain metastases remain a major clinical challenge and a leading cause of mortality....
5.
Sdeor E, Okada H, Saad R, Ben-Yishay T, Ben-David U
Nat Genet
. 2024 Oct;
56(10):2014-2026.
PMID: 39358600
Aneuploidy, an abnormal chromosome composition, is a major contributor to cancer development and progression and an important determinant of cancer therapeutic responses and clinical outcomes. Despite being recognized as a...
6.
Zerbib J, Ippolito M, Eliezer Y, De Feudis G, Reuveni E, Savir Kadmon A, et al.
Nat Commun
. 2024 Sep;
15(1):7772.
PMID: 39251587
Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with aneuploidy-induced cellular stresses remain largely unknown. Here, we induce chromosome mis-segregation in non-transformed RPE1-hTERT cells and...
7.
Ippolito M, Zerbib J, Eliezer Y, Reuveni E, Vigano S, De Feudis G, et al.
Cancer Discov
. 2024 Sep;
14(12):2532-2553.
PMID: 39247952
Aneuploidy results in a stoichiometric imbalance of protein complexes that jeopardizes cellular fitness. Aneuploid cells thus need to compensate for the imbalanced DNA levels by regulating their RNA and protein...
8.
Martin S, Scorzoni S, Cordone S, Mazzagatti A, Beznoussenko G, Gunn A, et al.
Science
. 2024 Aug;
385(6712):eadj7446.
PMID: 39208097
Chromosomal instability (CIN) generates micronuclei-aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements present in cancer. Micronuclei are characterized by persistent DNA damage and catastrophic nuclear envelope collapse,...
9.
Nair N, Schaffer A, Gertz E, Cheng K, Zerbib J, Sahu A, et al.
Cancer Res
. 2024 Jul;
84(20):3464-3477.
PMID: 39078448
The co-occurrence of chromosome 10 loss and chromosome 7 gain in gliomas is the most frequent loss-gain co-aneuploidy pair in human cancers. This phenomenon has been investigated since the late...
10.
Stavish D, Price C, Gelezauskaite G, Alsehli H, Leonhard K, Taapken S, et al.
Stem Cell Reports
. 2024 Jul;
19(8):1217-1232.
PMID: 38964325
Culture-acquired variants in human pluripotent stem cells (hPSCs) hinder their applications in research and clinic. However, the mechanisms that underpin selection of variants remain unclear. Here, through analysis of comprehensive...