Umesh Ghoshdastider
Overview
Explore the profile of Umesh Ghoshdastider including associated specialties, affiliations and a list of published articles.
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34
Citations
613
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Recent Articles
1.
Renz P, Ghoshdastider U, Baghai Sain S, Valdivia-Francia F, Khandekar A, Ormiston M, et al.
Nature
. 2024 Jul;
632(8024):419-428.
PMID: 39020166
The tumour evolution model posits that malignant transformation is preceded by randomly distributed driver mutations in cancer genes, which cause clonal expansions in phenotypically normal tissues. Although clonal expansions can...
2.
Ghoshdastider U, Sendoel A
Cell Rep
. 2023 Sep;
42(10):113172.
PMID: 37742190
Understanding the mechanisms underlying cancer gene expression is critical for precision oncology. Posttranscriptional regulation is a key determinant of protein abundance and cancer cell behavior. However, to what extent posttranscriptional...
3.
Efthymiou V, Ding L, Balaz M, Sun W, Balazova L, Straub L, et al.
Nat Commun
. 2023 Jul;
14(1):4162.
PMID: 37443109
The current obesity epidemic and high prevalence of metabolic diseases necessitate efficacious and safe treatments. Brown adipose tissue in this context is a promising target with the potential to increase...
4.
Weber R, Ghoshdastider U, Spies D, Dure C, Valdivia-Francia F, Forny M, et al.
Oncogene
. 2022 Dec;
42(9):638-650.
PMID: 36550360
Transcriptional and translational control are key determinants of gene expression, however, to what extent these two processes can be collectively coordinated is still poorly understood. Here, we use Nanopore long-read...
5.
Rohatgi N, Ghoshdastider U, Baruah P, Kulshrestha T, Skanderup A
Cell Rep
. 2022 May;
39(6):110800.
PMID: 35545044
Tumors are heterogeneous cellular environments with entwined metabolic dependencies. Here, we use a tumor transcriptome deconvolution approach to profile the metabolic states of cancer and non-cancer (stromal) cells in bulk...
6.
Balazova L, Balaz M, Horvath C, Horvath A, Moser C, Kovanicova Z, et al.
Nat Commun
. 2021 Dec;
12(1):7144.
PMID: 34880217
Activation of thermogenic brown and beige adipocytes is considered as a strategy to improve metabolic control. Here, we identify GPR180 as a receptor regulating brown and beige adipocyte function and...
7.
Mathes S, Fahrner A, Ghoshdastider U, Rudiger H, Leunig M, Wolfrum C, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(37).
PMID: 34493647
Aged skeletal muscle is markedly affected by fatty muscle infiltration, and strategies to reduce the occurrence of intramuscular adipocytes are urgently needed. Here, we show that fibroblast growth factor-2 (FGF-2)...
8.
Ghoshdastider U, Rohatgi N, Naeini M, Baruah P, Revkov E, Guo Y, et al.
Cancer Res
. 2021 Feb;
81(7):1802-1812.
PMID: 33547160
Signaling between cancer and nonmalignant (stromal) cells in the tumor microenvironment (TME) is a key to tumor progression. Here, we deconvoluted bulk tumor transcriptomes to infer cross-talk between ligands and...
9.
LaPierre M, Godbersen S, Torres Esteban M, Schad A, Treier M, Ghoshdastider U, et al.
Endocrinology
. 2020 Nov;
162(2).
PMID: 33248443
Prolactin production is controlled by a complex and temporally dynamic network of factors. Despite this tightly coordinated system, pathological hyperprolactinemia is a common endocrine disorder that is often not understood,...
10.
Kobiita A, Godbersen S, Araldi E, Ghoshdastider U, Schmid M, Spinas G, et al.
Cell Rep
. 2020 Jul;
32(1):107846.
PMID: 32640216
The ability of pancreatic β-cells to respond to increased demands for insulin during metabolic stress critically depends on proper ribosome homeostasis and function. Excessive and long-lasting stimulation of insulin secretion...