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Ulf Meyer-Hoffert

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Recent Articles
1.
Wu Z, Wu Y, Fischer J, Bartels J, Schroder J, Meyer-Hoffert U
J Invest Dermatol . 2018 Nov; 139(5):1135-1142. PMID: 30468739
Antimicrobial peptides play a critical role in the barrier function of human skin. They offer a fast response to invading microorganisms and protect from external microbial infection. Here we show...
2.
Weber C, Fischer J, Redelfs L, Rademacher F, Harder J, Weidinger S, et al.
Arch Dermatol Res . 2017 Aug; 309(9):767-771. PMID: 28852849
Proteases and their inhibitors play an important role in epidermal homeostasis. Their imbalance contributes to severe skin diseases. SPINK7 is a member of the SPINK protease inhibitor family and has...
3.
Plaza K, Kalinska M, Bochenska O, Meyer-Hoffert U, Wu Z, Fischer J, et al.
J Biol Chem . 2016 Jun; 291(36):18753-64. PMID: 27354280
Periodontitis, a chronic inflammation driven by dysbiotic subgingival bacterial flora, is linked on clinical levels to the development of a number of systemic diseases and to the development of oral...
4.
Jung S, Fischer J, Spudy B, Kerkow T, Sonnichsen F, Xue L, et al.
Biochem Biophys Res Commun . 2016 Feb; 471(1):103-8. PMID: 26828269
Kallikrein-related peptidases (KLKs) are crucial for epidermal barrier function and are involved in the proteolytic regulation of the desquamation process. Elevated KLK levels were reported in atopic dermatitis. In skin,...
5.
Redelfs L, Fischer J, Weber C, Wu Z, Meyer-Hoffert U
Arch Dermatol Res . 2016 Jan; 308(2):133-7. PMID: 26746658
The serine protease inhibitor of Kazal-type (SPINK) 9 was reported to be exclusively expressed in palmoplantar skin. SPINK9 is a specific inhibitor of the serine protease kallikrein-related peptidase 5 (KLK5),...
6.
Kalinska M, Meyer-Hoffert U, Kantyka T, Potempa J
Biochimie . 2015 Sep; 122:270-82. PMID: 26408415
The human tissue kallikrein and kallikrein-related peptidases (KLKs), encoded by the largest contiguous cluster of protease genes in the human genome, are secreted serine proteases with diverse expression patterns and...
7.
Schaarschmidt H, Ellinghaus D, Rodriguez E, Kretschmer A, Baurecht H, Lipinski S, et al.
J Allergy Clin Immunol . 2015 Apr; 136(3):802-6. PMID: 25865352
No abstract available.
8.
Glaser R, Becker K, von Eiff C, Meyer-Hoffert U, Harder J
J Invest Dermatol . 2014 Apr; 134(9):2347-2350. PMID: 24717245
Staphylococcus aureus is a frequent resident of human nose and skin in many individuals, but it is also able to cause a variety of serious infections including those of the...
9.
Sperrhacke M, Fischer J, Wu Z, Klunder S, Sedlacek R, Schroeder J, et al.
J Invest Dermatol . 2014 Jan; 134(6):1645-1654. PMID: 24441102
Serine protease inhibitors of the Kazal-type 9 (SPINK9) is a keratinocyte-derived cationic peptide that is found most abundantly in the upper layers of the palmar-plantar epidermis. In vitro, the peptide...
10.
Fischer J, Wu Z, Kantyka T, Sperrhacke M, Dimitrieva O, Koblyakova Y, et al.
J Invest Dermatol . 2013 Dec; 134(5):1305-1312. PMID: 24352040
The proteolytic regulation of the desquamation process by kallikrein-related peptidases (KLKs) is crucial for epidermal barrier function, and elevated KLK levels have been reported in atopic dermatitis. KLKs are controlled...