Ulf Lindahl
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Explore the profile of Ulf Lindahl including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Lindahl U
Matrix Biol
. 2014 Jan;
35:3-7.
PMID: 24463261
The concept of "proteoglycans" as discrete molecules surfaced some 40 years ago, out of previously muddled notions of the extracellular matrix. Core proteins were gradually recognized as molecular entities, distinct...
12.
Ramachandra R, Namburi R, Ortega-Martinez O, Shi X, Zaia J, Dupont S, et al.
Glycobiology
. 2013 Nov;
24(2):195-207.
PMID: 24253764
Glycosaminoglycans (GAGs) isolated from brittlestars, Echinodermata class Ophiuroidea, were characterized, as part of attempts to understand the evolutionary development of these polysaccharides. A population of chondroitin sulfate/dermatan sulfate (CS/DS) chains...
13.
Zhang X, Wang B, OCallaghan P, Hjertstrom E, Jia J, Gong F, et al.
Acta Neuropathol
. 2012 Jun;
124(4):465-78.
PMID: 22692572
Neuroinflammation is typically observed in neurodegenerative diseases such as Alzheimer's disease, as well as after traumatic injury and pathogen infection. Resident immune cells, microglia and astrocytes, are activated and joined...
14.
Kusche-Gullberg M, Nybakken K, Perrimon N, Lindahl U
J Biol Chem
. 2012 May;
287(26):21950-6.
PMID: 22556423
Heparan sulfate (HS) proteoglycans play critical roles in a wide variety of biological processes such as growth factor signaling, cell adhesion, wound healing, and tumor metastasis. Functionally important interactions between...
15.
Karlsson-Lindahl L, Schmidt L, Haage D, Hansson C, Taube M, Egecioglu E, et al.
PLoS One
. 2012 Apr;
7(3):e34313.
PMID: 22479599
Mutation of the melanocortin-receptor 4 (MC4R) is the most frequent cause of severe obesity in humans. Binding of agouti-related peptide (AgRP) to MC4R involves the co-receptor syndecan-3, a heparan sulfate...
16.
Jastrebova N, Vanwildemeersch M, Lindahl U, Spillmann D
J Biol Chem
. 2010 Jun;
285(35):26842-26851.
PMID: 20576609
Heparan sulfates (HSs) modulate various developmental and homeostatic processes by binding to protein ligands. We have evaluated the structural characteristics of porcine HS in cellular signaling induced by basic fibroblast...
17.
Sandwall E, OCallaghan P, Zhang X, Lindahl U, Lannfelt L, Li J
Glycobiology
. 2010 Jan;
20(5):533-41.
PMID: 20053627
Heparan sulfate (HS) has been found associated with amyloid deposits, including the toxic amyloid-beta (Abeta) peptide aggregates in cerebral vasculature and neuronal tissues in patients with Alzheimer's disease. However, the...
18.
Ekman-Ordeberg G, Hellgren M, Akerud A, Andersson E, Dubicke A, Sennstrom M, et al.
Acta Obstet Gynecol Scand
. 2009 Aug;
88(9):984-9.
PMID: 19657754
Objectives: The low molecular weight heparin, Dalteparin, shortens human labor time. The aim of this study was to investigate if the mechanism behind this effect involves myometrial contractility and cervical...
19.
Lindahl U, Li J
Int Rev Cell Mol Biol
. 2009 Jul;
276:105-59.
PMID: 19584012
Heparan sulfate (HS) proteoglycans at cell surfaces and in the extracellular matrix of most animal tissues are essential in development and homeostasis, and variously implicated in disease processes. Functions of...
20.
Zcharia E, Jia J, Zhang X, Baraz L, Lindahl U, Peretz T, et al.
PLoS One
. 2009 Apr;
4(4):e5181.
PMID: 19360105
Background: Heparanase, a mammalian endo-beta-D-glucuronidase, specifically degrades heparan sulfate proteoglycans ubiquitously associated with the cell surface and extracellular matrix. This single gene encoded enzyme is over-expressed in most human cancers,...