Ulf Landegren
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Explore the profile of Ulf Landegren including associated specialties, affiliations and a list of published articles.
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144
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5550
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Recent Articles
31.
Ebai T, Marques Souza de Oliveira F, Lof L, Wik L, Schweiger C, Larsson A, et al.
Clin Chem
. 2017 Jul;
63(9):1497-1505.
PMID: 28667186
Background: Detecting proteins at low concentrations in plasma is crucial for early diagnosis. Current techniques in clinical routine, such as sandwich ELISA, provide sensitive protein detection because of a dependence...
32.
Lonn P, Landegren U
Trends Biochem Sci
. 2017 Jun;
42(7):504-515.
PMID: 28566215
The well-oiled machinery of the cellular proteome operates via variable expression, modifications, and interactions of proteins, relaying genomic and transcriptomic information to coordinate cellular functions. In recent years, a number...
33.
Bjorkesten J, Enroth S, Shen Q, Wik L, Hougaard D, Cohen A, et al.
Mol Cell Proteomics
. 2017 May;
16(7):1286-1296.
PMID: 28501802
An important motivation for the construction of biobanks is to discover biomarkers that identify diseases at early, potentially curable stages. This will require biobanks from large numbers of individuals, preferably...
34.
Padhan N, Yan J, Boge A, Scrivener E, Birgisson H, Zieba A, et al.
Sci Rep
. 2017 May;
7(1):1490.
PMID: 28473697
Detection and quantification of proteins and their post-translational modifications are crucial to decipher functions of complex protein networks in cell biology and medicine. Capillary isoelectric focusing together with antibody-based detection...
35.
Lof L, Arngarden L, Olsson-Stromberg U, Siart B, Jansson M, Dahlin J, et al.
Sci Rep
. 2017 Apr;
7(1):623.
PMID: 28377570
Chronic myeloid leukemia (CML) is characterized in the majority of cases by a t(9;22)(q34;q11) translocation, also called the Philadelphia chromosome, giving rise to the BCR-ABL1 fusion protein. Current treatment with...
36.
Schutte M, Risch T, Abdavi-Azar N, Boehnke K, Schumacher D, Keil M, et al.
Nat Commun
. 2017 Feb;
8:14262.
PMID: 28186126
Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address...
37.
Larssen P, Wik L, Czarnewski P, Eldh M, Lof L, Ronquist K, et al.
Mol Cell Proteomics
. 2017 Jan;
16(3):502-511.
PMID: 28111361
Extracellular vesicles (EVs) are membrane-coated objects such as exosomes and microvesicles, released by many cell-types. Their presence in body fluids and the variable surface composition and content render them attractive...
38.
Lof L, Ebai T, Dubois L, Wik L, Ronquist K, Nolander O, et al.
Sci Rep
. 2016 Sep;
6:34358.
PMID: 27681459
Flow cytometry is a powerful method for quantitative and qualitative analysis of individual cells. However, flow cytometric analysis of extracellular vesicles (EVs), and the proteins present on their surfaces has...
39.
Genshaft A, Li S, Gallant C, Darmanis S, Prakadan S, Ziegler C, et al.
Genome Biol
. 2016 Sep;
17(1):188.
PMID: 27640647
We present a scalable, integrated strategy for coupled protein and RNA detection from single cells. Our approach leverages the DNA polymerase activity of reverse transcriptase to simultaneously perform proximity extension...
40.
Detection of Biomarkers with Solid-Phase Proximity Ligation Assay in Patients with Colorectal Cancer
Ghanipour L, Darmanis S, Landegren U, Glimelius B, Pahlman L, Birgisson H
Transl Oncol
. 2016 Jun;
9(3):251-5.
PMID: 27267845
Background: In the search for prognostic biomarkers, a significant amount of precious biobanked blood samples is needed for conventional analyses. Solid-phase proximity ligation assay (SP-PLA) is an analytic method with...