Ulf Brockmeier
Overview
Explore the profile of Ulf Brockmeier including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
999
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0
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Recent Articles
1.
Mohamud Yusuf A, Borbor M, Hussner T, Weghs C, Kaltwasser B, Pillath-Eilers M, et al.
Cell Death Dis
. 2024 Sep;
15(9):650.
PMID: 39231943
Acid sphingomyelinase (ASM) inhibitors are widely used for the treatment of post-stroke depression. They promote neurological recovery in animal stroke models via neurorestorative effects. In a previous study, we found...
2.
Liu X, Ye Q, Huang Z, Li X, Zhang L, Liu X, et al.
Stroke
. 2023 Jun;
54(8):2114-2125.
PMID: 37377010
Background: The ubiquitin-proteasome system (UPS) and autophagy are 2 major protein degradation pathways in eukaryotic cells. We previously identified a switch from UPS to autophagy with changes in BAG3 (B-cell...
3.
Borbor M, Yin D, Brockmeier U, Wang C, Doeckel M, Pillath-Eilers M, et al.
Glia
. 2023 Feb;
71(6):1553-1569.
PMID: 36810803
Astrocytic responses are critical for the maintenance of neuronal networks in health and disease. In stroke, reactive astrocytes undergo functional changes potentially contributing to secondary neurodegeneration, but the mechanisms of...
4.
Doeppner T, Coman C, Burdusel D, Ancuta D, Brockmeier U, Pirici D, et al.
Aging (Albany NY)
. 2022 May;
14(10):4195-4210.
PMID: 35609021
Previous studies have shown that the polyamine spermidine increased the maximum life span in and the median life span in mice. Since spermidine increases autophagy, we asked if treatment with...
5.
Ocklenburg T, Neumann F, Wolf A, Vogel J, Gopelt K, Baumann M, et al.
Sci Rep
. 2021 Mar;
11(1):7199.
PMID: 33785835
The disulfide isomerase ERp57, originally found in the endoplasmic reticulum, is located in multiple cellular compartments, participates in diverse cell functions and interacts with a huge network of binding partners....
6.
Kuper A, Baumann J, Gopelt K, Baumann M, Sanger C, Metzen E, et al.
Cell Death Dis
. 2021 Jan;
12(1):82.
PMID: 33441543
Hypoxia-induced resistance of tumor cells to therapeutic treatment is an unresolved limitation due to poor vascular accessibility and protective cell adaptations provided by a network, including PERK, NRF2, and HIF...
7.
Kranz P, Sanger C, Wolf A, Baumann J, Metzen E, Baumann M, et al.
Sci Rep
. 2020 Sep;
10(1):15299.
PMID: 32943707
Upon ER stress cells activate the unfolded protein response through PERK, IRE1 and ATF6. Remarkable effort has been made to delineate the downstream signaling of these three ER stress sensors...
8.
Bernardini A, Wolf A, Brockmeier U, Riffkin H, Metzen E, Acker-Palmer A, et al.
Am J Physiol Cell Physiol
. 2020 Jan;
318(4):C719-C731.
PMID: 31967857
Carotid body (CB) type I cells sense the blood Po and generate a nervous signal for stimulating ventilation and circulation when blood oxygen levels decline. Three oxygen-sensing enzyme complexes may...
9.
Pompsch M, Vogel J, Classen F, Kranz P, Iliakis G, Riffkin H, et al.
BMC Cancer
. 2018 Dec;
18(1):1190.
PMID: 30497423
Background: The nudix family member enzyme MutT homologue-1 (MTH1) hydrolyses the oxidized nucleotides 8-oxo-dGTP and 2-hydroxy-dATP and thus prevents the incorporation of damaged nucleotides into nuclear and mitochondrial DNA. Therefore...
10.
Classen F, Kranz P, Riffkin H, Pompsch M, Wolf A, Gopelt K, et al.
Exp Cell Res
. 2018 Nov;
374(1):29-37.
PMID: 30412717
Autophagy is commonly described as a cell survival mechanism and has been implicated in chemo- and radioresistance of cancer cells. Whether ionizing radiation induced autophagy triggers tumor cell survival or...