U Thorsteinsdottir
Overview
Explore the profile of U Thorsteinsdottir including associated specialties, affiliations and a list of published articles.
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21
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1441
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Recent Articles
11.
Helgadottir A, Gretarsdottir S, St Clair D, Manolescu A, Cheung J, Thorleifsson G, et al.
Am J Hum Genet
. 2005 Jan;
76(3):505-9.
PMID: 15640973
Cardiovascular diseases, including myocardial infarction (MI) and stroke, most often occur on the background of atherosclerosis, a condition attributed to the interactions between multiple genetic and environmental risk factors. We...
12.
NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice
Kroon E, Thorsteinsdottir U, Mayotte N, Nakamura T, Sauvageau G
EMBO J
. 2001 Feb;
20(3):350-61.
PMID: 11157742
Here we describe hemopoietic chimeras serving as a mouse model for NUP98-HOXA9-induced leukemia, which reproduced several of the phenotypes observed in human disease. Mice transplanted with bone marrow cells expressing...
13.
Thorsteinsdottir U, Kroon E, Jerome L, Blasi F, Sauvageau G
Mol Cell Biol
. 2000 Dec;
21(1):224-34.
PMID: 11113197
Complex genetic and biochemical interactions between HOX proteins and members of the TALE (i.e., PBX and MEIS) family have been identified in embryonic development, and some of these interactions also...
14.
Lessard J, Schumacher A, Thorsteinsdottir U, van Lohuizen M, Magnuson T, Sauvageau G
Genes Dev
. 1999 Oct;
13(20):2691-703.
PMID: 10541555
The murine Polycomb-Group (PcG) proteins Eed and Bmi1 govern axial patterning during embryonic development by segment-specific repression of Hox gene expression. The two proteins engage in distinct multimeric complexes that...
15.
Thorsteinsdottir U, Sauvageau G, Humphries R
Blood
. 1999 Oct;
94(8):2605-12.
PMID: 10515864
After bone marrow transplantation (BMT), there is a rapid regeneration to normal pretransplantation levels in the number of hematopoietic progenitors and mature end cells, whereas hematopoietic stem cell (HSC) numbers...
16.
Thorsteinsdottir U, Krosl J, Kroon E, Haman A, Hoang T, Sauvageau G
Mol Cell Biol
. 1999 Aug;
19(9):6355-66.
PMID: 10454582
A recurrent translocation between chromosome 1 (Pbx1) and 19 (E2A) leading to the expression of the E2A-Pbx1 fusion oncoprotein occurs in approximately 5 to 10% of acute leukemias in humans....
17.
Kroon E, Krosl J, Thorsteinsdottir U, Baban S, Buchberg A, Sauvageau G
EMBO J
. 1998 Jul;
17(13):3714-25.
PMID: 9649441
Hoxa9, Meis1 and Pbx1 encode homeodomaincontaining proteins implicated in leukemic transformation in both mice and humans. Hoxa9, Meis1 and Pbx1 proteins have been shown to physically interact with each other,...
18.
Thorsteinsdottir U, Sauvageau G, Humphries R
Hematol Oncol Clin North Am
. 1998 Jan;
11(6):1221-37.
PMID: 9443054
Hox genes, first recognized for their role in embryonic development, may also play lineage-specific functions in a variety of somatic tissues including the hematopoietic system. Expression of these transcription factors...
19.
Sauvageau G, Thorsteinsdottir U, Hough M, Hugo P, Lawrence H, Largman C, et al.
Immunity
. 1997 Jan;
6(1):13-22.
PMID: 9052833
HOXB3 mRNA levels are high in the earliest CD34+ lineage- bone marrow cells and low to undetectable in later CD34+/CD34- cells. To gain some insight into the role this gene...
20.
Thorsteinsdottir U, Sauvageau G, Hough M, Dragowska W, Lansdorp P, Lawrence H, et al.
Mol Cell Biol
. 1997 Jan;
17(1):495-505.
PMID: 8972230
Multiple members of the A, B, and C clusters of Hox genes are expressed in hematopoietic cells. Several of these Hox genes have been found to display distinctive expression patterns,...