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U Kapp

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Recent Articles
11.
Kapp U, Bhatia M, Bonnet D, Murdoch B, Dick J
Blood . 1998 Sep; 92(6):2024-31. PMID: 9731060
Until recently, the identification of cellular factors that govern the developmental program of human stem cells has been difficult due to the absence of repopulation assays that detect human stem...
12.
Weichenrieder O, Kapp U, Cusack S, Strub K
RNA . 1997 Dec; 3(11):1262-74. PMID: 9409618
We have identified functionally and analyzed a minimal Alu RNA folding domain that is recognized by SRPphi14-9. Recombinant SRPphi14-9 is a fusion protein containing on a single polypeptide chain the...
13.
Hammermann M, Steinmaier C, Merlitz H, Kapp U, Waldeck W, Chirico G, et al.
Biophys J . 1997 Nov; 73(5):2674-87. PMID: 9370461
Using laser light scattering, we have measured the static and dynamic structure factor of two different superhelical DNAs, p1868 (1868 bp) and simian virus 40 (SV40) (5243 bp), in dilute...
14.
Bhatia M, Bonnet D, Kapp U, Wang J, Murdoch B, Dick J
J Exp Med . 1997 Aug; 186(4):619-24. PMID: 9254660
Ex vivo culture of human hematopoietic cells is a crucial component of many therapeutic applications. Although current culture conditions have been optimized using quantitative in vitro progenitor assays, knowledge of...
15.
Birse D, Kapp U, Strub K, Cusack S, Aberg A
EMBO J . 1997 Jul; 16(13):3757-66. PMID: 9233785
The mammalian signal recognition particle (SRP) is an 11S cytoplasmic ribonucleoprotein that plays an essential role in protein sorting. SRP recognizes the signal sequence of the nascent polypeptide chain emerging...
16.
Bhatia M, Wang J, Kapp U, Bonnet D, Dick J
Proc Natl Acad Sci U S A . 1997 May; 94(10):5320-5. PMID: 9144235
The purification of primitive human hematopoietic stem cells has been impaired by the absence of repopulation assays. By using a stringent two-step strategy involving depletion of lineage-positive cells followed by...
17.
Dick J, Bhatia M, Gan O, Kapp U, Wang J
Stem Cells . 1997 Jan; 15 Suppl 1:199-203; discussion 204-7. PMID: 9368342
The only conclusive method to assay stem cells is to follow their ability to repopulate conditioned recipients, making it difficult to study human stem cells. The development of systems to...
18.
Doublie S, Kapp U, Aberg A, Brown K, Strub K, Cusack S
FEBS Lett . 1996 Apr; 384(3):219-21. PMID: 8617357
Two different crystal forms of the 9 kDa protein of the signal recognition particle (SRP9) have been prepared by the hanging drop vapor diffusion technique using 28% (w/v) PEG8000 or...
19.
Birse D, Doublie S, Kapp U, Strub K, Cusack S, Aberg A
FEBS Lett . 1996 Apr; 384(3):215-8. PMID: 8617356
The SRPphi14-9 fusion protein, which can functionally replace the SRP9/14 heterodimer in the mammalian signal recognition particle (SRP), has been crystallized using the vapor diffusion method. Four different crystal forms...
20.
KANZLER H, Hansmann M, Kapp U, Wolf J, Diehl V, Rajewsky K, et al.
Blood . 1996 Apr; 87(8):3429-36. PMID: 8605361
A novel cell line, L1236, was established from the peripheral blood of a patient with Hodgkin's disease (HD). Two Ig VH and one Vkappa gene rearrangements were amplified by polymerase...