Tyzoon K Nomanbhoy
Overview
Explore the profile of Tyzoon K Nomanbhoy including associated specialties, affiliations and a list of published articles.
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20
Citations
1228
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Recent Articles
1.
Zhu W, Radadiya A, Bisson C, Wenzel S, Nordin B, Martinez-Marquez F, et al.
Commun Biol
. 2019 Dec;
2:438.
PMID: 31799439
[This corrects the article DOI: 10.1038/s42003-019-0587-z.].
2.
Zhu W, Radadiya A, Bisson C, Wenzel S, Nordin B, Martinez-Marquez F, et al.
Commun Biol
. 2019 Sep;
2:345.
PMID: 31552298
Expression of human asparagine synthetase (ASNS) promotes metastatic progression and tumor cell invasiveness in colorectal and breast cancer, presumably by altering cellular levels of L-asparagine. Human ASNS is therefore emerging...
3.
Okerberg E, Dagbay K, Green J, Soni I, Aban A, Nomanbhoy T, et al.
Biochemistry
. 2019 May;
58(52):5320-5328.
PMID: 31095371
Acyl phosphates of ATP (ATPAc) and related nucleotides have proven to be useful for the interrogation of known nucleotide binding sites via specific acylation of conserved lysines (K). In addition,...
4.
Lin E, Amantea C, Nomanbhoy T, Weissig H, Ishiyama J, Hu Y, et al.
Proc Natl Acad Sci U S A
. 2016 Sep;
113(42):11865-11870.
PMID: 27679845
Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal canonical kinase domain. Genetic deletion of ERK5 is...
5.
Nomanbhoy T, Sharma G, Brown H, Wu J, Aban A, Vogeti S, et al.
Biochemistry
. 2016 Aug;
55(38):5434-41.
PMID: 27571378
Palbociclib is a cyclin-dependent kinase (CDK) 4/CDK6 inhibitor approved for breast cancer that is estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative. We profiled palbociclib in cells...
6.
Matthews J, Bhatt S, Patricelli M, Nomanbhoy T, Jiang X, Natkunam Y, et al.
Blood
. 2016 May;
128(2):239-48.
PMID: 27151888
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, yet 40% to 50% of patients will eventually succumb to their disease, demonstrating a pressing need for...
7.
Nordin B, Liu Y, Aban A, Brown H, Wu J, Hainley A, et al.
Biochemistry
. 2015 Apr;
54(19):3024-36.
PMID: 25905789
Hsp90 is an ATP-dependent chaperone of widespread interest as a drug target. Here, using an LC-MS/MS chemoproteomics platform based on a lysine-reactive ATP acyl phosphate probe, several Hsp90 inhibitors were...
8.
Okerberg E, Shih A, Brown H, Alemayehu S, Aban A, Nomanbhoy T
Curr Protoc Chem Biol
. 2014 Jan;
5(3):213-26.
PMID: 24391084
The protocols in this unit describe efficient and cost-effective approaches to determine the interaction of small-molecule inhibitors with native kinases, and also analyze the interactions between kinases and their binding...
9.
Rosenblum J, Nomanbhoy T, Kozarich J
FEBS Lett
. 2013 May;
587(13):1870-7.
PMID: 23684650
The largest mammalian enzyme family is the kinases. Kinases and other nucleotide-binding proteins are key regulators of signal transduction pathways and the mutation or overexpression of these proteins is often...
10.
Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro S, Machleidt T, et al.
Chem Biol
. 2012 Jan;
19(1):140-54.
PMID: 22284361
The mitogen-activated kinases JNK1/2/3 are key enzymes in signaling modules that transduce and integrate extracellular stimuli into coordinated cellular response. Here, we report the discovery of irreversible inhibitors of JNK1/2/3....