Tyler Malys
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Explore the profile of Tyler Malys including associated specialties, affiliations and a list of published articles.
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10
Citations
83
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Recent Articles
1.
Ibanez K, Donohue D, Malys T, Lee J
Sci Rep
. 2024 Jul;
14(1):17459.
PMID: 39075200
We investigated the association of CA125 response with prognosis and RECIST response/progressive disease (PD) criteria in recurrent high grade serous ovarian cancer (HGSOC) patients treated with a cell cycle checkpoint...
2.
Giudice E, Huang T, Nair J, Zurcher G, McCoy A, Nousome D, et al.
Nat Commun
. 2024 Mar;
15(1):2805.
PMID: 38555285
The multi-cohort phase 2 trial NCT02203513 was designed to evaluate the clinical activity of the CHK1 inhibitor (CHK1i) prexasertib in patients with breast or ovarian cancer. Here we report the...
3.
Sengodan S, Hu X, Peddibhotla V, Balamurugan K, Mitrophanov A, McKennett L, et al.
J Clin Invest
. 2024 Jan;
134(7).
PMID: 38271119
Loss of BRCA2 (breast cancer 2) is lethal for normal cells. Yet it remains poorly understood how, in BRCA2 mutation carriers, cells undergoing loss of heterozygosity overcome the lethality and...
4.
Biswas K, Mitrophanov A, Sahu S, Sullivan T, Southon E, Nousome D, et al.
Cell Rep Methods
. 2023 Nov;
3(11):100628.
PMID: 37922907
Sequencing of genes, such as BRCA1 and BRCA2, is recommended for individuals with a personal or family history of early onset and/or bilateral breast and/or ovarian cancer or a history...
5.
Sahu S, Sullivan T, Mitrophanov A, Galloux M, Nousome D, Southon E, et al.
PLoS Genet
. 2023 Sep;
19(9):e1010940.
PMID: 37713444
The unknown pathogenicity of a significant number of variants found in cancer-related genes is attributed to limited epidemiological data, resulting in their classification as variant of uncertain significance (VUS). To...
6.
Newton H, Zhang J, Donohue D, Unnithan R, Cedrone E, Xu J, et al.
Front Allergy
. 2023 Jul;
4:1126012.
PMID: 37470031
Introduction: Immunophenotyping, which is the identification of immune cell subsets based on antigen expression, is an integral technique used to determine changes of cell composition and activation in various disease...
7.
Pandkar M, Raveendran A, Biswas K, Mutnuru S, Mishra J, Samaiya A, et al.
NAR Cancer
. 2023 Jun;
5(3):zcad032.
PMID: 37388539
The hypoxic milieu is a critical modulator of aerobic glycolysis, yet the regulatory mechanisms between the key glycolytic enzymes in hypoxic cancer cells are largely unchartered. In particular, the M2...
8.
Swanstrom A, Immonen T, Oswald K, Pyle C, Thomas J, Bosche W, et al.
J Clin Invest
. 2021 Jan;
131(6).
PMID: 33465055
The effectiveness of virus-specific strategies, including administered HIV-specific mAbs, to target cells that persistently harbor latent, rebound-competent HIV genomes during combination antiretroviral therapy (cART) has been limited by inefficient induction...
9.
Del Prete G, Alvord W, Li Y, Deleage C, Nag M, Oswald K, et al.
JCI Insight
. 2019 Jun;
4(11).
PMID: 31167974
Reduction/elimination of HIV-1 reservoirs that persist despite combination antiretroviral therapy (cART) will likely require induction of viral expression by residual infected cells and enhanced clearance of these cells. TLR7 agonists...
10.
Microbial communities present in the lower respiratory tract of clinically healthy birds in Pakistan
Shabbir M, Malys T, Ivanov Y, Park J, Shabbir M, Rabbani M, et al.
Poult Sci
. 2015 Feb;
94(4):612-20.
PMID: 25667427
Commercial poultry is an important agricultural industry worldwide. Although dense living conditions and large flocks increase meat and egg production, they also increase the risk of disease outbreaks and zoonoses....