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Tsz Fung Tsang

Explore the profile of Tsz Fung Tsang including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 9
Citations 42
Followers 0
Related Specialties
Chemistry
Biochemistry
Microbiology
Top 10 Co-Authors
Xiao Yang
Cong Ma
Margaret Ip
Yangyi Qiu
Adrian Jun Chu
Lin Lin
Zhong Zuo
Nilakshi Barua
Yingbo Zheng
Cheuk Hei Kan
Published In
Bioorg Chem
ACS Infect Dis
PLoS One
J Med Chem
Eur J Med Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Inter-individual variability in the metabolism of psychotropic drugs by the enzyme activities from the human gut microbiome
Wang X, Lyu Y, Cheng S, Tsang T, Chong K, Boon S, et al.
J Pharm Biomed Anal . 2025 Feb; 258:116717. PMID: 39919466
The interaction between marketed drugs and the gut microbiome is increasingly being recognized, and it is now known that enzymes produced by the bacteria in the human gut can degrade...
2.
Discovery of Inhibitors Targeting Protein-Protein Interaction between Bacterial RNA Polymerase and NusG as Novel Antimicrobials
Zheng Y, Kan C, Tsang T, Liu Y, Liu T, Tsang M, et al.
J Med Chem . 2024 Aug; 67(18):16556-16575. PMID: 39196895
Bacterial RNA polymerase (RNAP), the core enzyme responsible for bacterial transcription, requires the NusG factor for efficient transcription elongation and termination. As the primary binding site for NusG, the RNAP...
3.
Development of a luciferase-based Gram-positive bacterial reporter system for the characterization of antimicrobial agents
Lam N, Tsang T, Qu J, Tsang M, Tao Y, Kan C, et al.
Appl Environ Microbiol . 2024 Jul; 90(8):e0071724. PMID: 39016615
Importance: Discovering new classes of antibiotics is desperately needed to combat the emergence of multidrug-resistant pathogens. To facilitate the drug discovery process, a simple cell-based assay for mechanistic studies is...
4.
Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resistant bacteria
Ye J, Kan C, Zheng Y, Tsang T, Chu A, Chan K, et al.
Bioorg Chem . 2023 Nov; 143:106983. PMID: 38016396
RNA polymerase is an essential enzyme involved in bacterial transcription, playing a crucial role in RNA synthesis. However, it requires the association with sigma factors to initiate this process. In...
5.
Rapid SARS-CoV-2 Variants Enzymatic Detection (SAVED) by CRISPR-Cas12a
Yang J, Barua N, Rahman M, Li C, Lo N, Yeong K, et al.
Microbiol Spectr . 2022 Nov; 10(6):e0326022. PMID: 36342324
The continuous and rapid surge of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with high transmissibility and evading neutralization is alarming, necessitating expeditious detection of the variants concerned. Here,...
6.
Synthesis and biological evaluation of nusbiarylin derivatives as bacterial rRNA synthesis inhibitor with potent antimicrobial activity against MRSA and VRSA
Qiu Y, Chu A, Tsang T, Zheng Y, Lam N, Li K, et al.
Bioorg Chem . 2022 May; 124:105863. PMID: 35580381
Bacterial transcription is a valid but underutilized target for antimicrobial agent discovery because of its function of bacterial RNA synthesis. Bacterial transcription factors NusB and NusE form a transcription complex...
7.
Chimeric crRNA improves CRISPR-Cas12a specificity in the N501Y mutation detection of Alpha, Beta, Gamma, and Mu variants of SARS-CoV-2
Yang J, Barua N, Rahman M, Lo N, Tsang T, Yang X, et al.
PLoS One . 2021 Dec; 16(12):e0261778. PMID: 34941928
Many CRISPR/Cas platforms have been established for the detection of SARS-CoV-2. But the detection platform of the variants of SARS-CoV-2 is scarce because its specificity is very challenging to achieve...
8.
Nusbiarylins, a new class of antimicrobial agents: Rational design of bacterial transcription inhibitors targeting the interaction between the NusB and NusE proteins
Qiu Y, Chan S, Lin L, Shek T, Tsang T, Zhang Y, et al.
Bioorg Chem . 2019 Aug; 92:103203. PMID: 31446238
Discovery of antibiotics of a novel mode of action is highly required in the fierce battlefield with multi-drug resistant bacterial infections. Previously we have validated the protein-protein interaction between bacterial...
9.
Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins
Qiu Y, Chan S, Lin L, Shek T, Tsang T, Barua N, et al.
Eur J Med Chem . 2019 Jun; 178:214-231. PMID: 31185412
Discovery of antimicrobial agents with a novel model of action is in urgent need for the clinical management of multidrug-resistant bacterial infections. Recently, we reported the identification of a first-in-class...
10.
Simple Method for Studying in Vitro Protein-Protein Interactions Based on Protein Complementation and Its Application in Drug Screening Targeting Bacterial Transcription
Tsang T, Qiu Y, Lin L, Ye J, Ma C, Yang X
ACS Infect Dis . 2019 Mar; 5(4):521-527. PMID: 30834747
Protein-protein interactions (PPIs) underpin essential cellular processes of all organisms and are increasingly considered as drug targets. A number of techniques have been established to study PPIs; however, development of...