Tsuyoshi Konuma
Overview
Explore the profile of Tsuyoshi Konuma including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
652
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Recent Articles
1.
Inoue R, Oda T, Nakagawa H, Tominaga T, Ikegami T, Konuma T, et al.
Biophys J
. 2024 Dec;
124(3):540-548.
PMID: 39719827
Intrinsically disordered proteins (IDPs) show structural changes stimulated by changes in external conditions. This study aims to reveal the temperature dependence of the structure and the dynamics of the intrinsically...
2.
Shiraishi N, Konuma T, Chiba Y, Hokazono S, Nakamura N, Islam M, et al.
Commun Biol
. 2024 Jun;
7(1):746.
PMID: 38898124
DNA methylation maintenance is essential for cell fate inheritance. In differentiated cells, this involves orchestrated actions of DNMT1 and UHRF1. In mice, the high-affinity binding of DPPA3 to the UHRF1...
3.
Konuma T, Takai T, Tsuchiya C, Nishida M, Hashiba M, Yamada Y, et al.
Protein Sci
. 2024 May;
33(6):e5002.
PMID: 38723146
Bacteria that have acquired resistance to most antibiotics, particularly those causing nosocomial infections, create serious problems. Among these, the emergence of vancomycin-resistant enterococci was a tremendous shock, considering that vancomycin...
4.
Suzuki N, Konuma T, Ikegami T, Akashi S
Protein Sci
. 2024 Apr;
33(5):e4994.
PMID: 38647411
Sirtuin 2 (SIRT2) is a class III histone deacetylase that is highly conserved from bacteria to mammals. We prepared and characterized the wild-type (WT) and mutant forms of the histone...
5.
Hokazono S, Imagawa E, Hirano D, Ikegami T, Oishi K, Konuma T
Biomol NMR Assign
. 2024 Mar;
18(1):59-63.
PMID: 38451454
Hepatocyte nuclear factor 1β (HNF1β) is a transcription factor that plays a key role in the development and function of the liver, pancreas, and kidney. HNF1β plays a key role...
6.
Konuma T, Zhou M
J Mol Biol
. 2023 Dec;
436(7):168376.
PMID: 38056822
Site-specific histone modifications have long been recognized to play an important role in directing gene transcription in chromatin in biology of health and disease. However, concrete illustration of how different...
7.
Komura K, Hirosuna K, Tokushige S, Tsujino T, Nishimura K, Ishida M, et al.
Mol Cancer
. 2023 Nov;
22(1):185.
PMID: 37980528
Background: Currently, only limited knowledge is available regarding the phenotypic association between fibroblast growth factor receptor 3 (FGFR3) alterations and the tumor microenvironment (TME) in bladder cancer (BLCA). Methods: A...
8.
Kikuchi M, Takase S, Konuma T, Noritsugu K, Sekine S, Ikegami T, et al.
Proc Natl Acad Sci U S A
. 2023 Oct;
120(43):e2304103120.
PMID: 37844223
Glioma amplified sequence 41 (GAS41), which has the Yaf9, ENL, AF9, Taf14, and Sas5 (YEATS) domain that recognizes lysine acetylation (Kac), regulates gene expression as a subunit of the SRCAP...
9.
Tajiri M, Imai S, Konuma T, Shimamoto K, Shimada I, Akashi S
ACS Omega
. 2023 Jul;
8(27):24544-24551.
PMID: 37457453
We aimed to develop a platform to rapidly investigate the responses of agonists and antagonists to G-protein-coupled receptors (GPCRs) using native mass spectrometry (MS). We successfully observed the ligand-bound human...
10.
Liu N, Konuma T, Sharma R, Wang D, Zhao N, Cao L, et al.
Mol Cell
. 2023 Jun;
83(13):2206-2221.e11.
PMID: 37311463
Histone lysine acylation, including acetylation and crotonylation, plays a pivotal role in gene transcription in health and diseases. However, our understanding of histone lysine acylation has been limited to gene...