Tsung Wai Kan
Overview
Explore the profile of Tsung Wai Kan including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
265
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0
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Recent Articles
1.
Scholtes M, Akbarzadeh M, Galaras A, Nakauma-Gonzales J, Bazrafshan A, Solanki V, et al.
Cancer Lett
. 2025 Feb;
614:217506.
PMID: 39892702
Somatic mutations in ARID1A (AT-rich interactive domain-containing protein 1A) are present in approximately 25 % of bladder cancers (BC) and are associated with poor prognosis. With a view to discover...
2.
Hossain T, Lungu C, de Schrijver S, Kuali M, Crespo R, Reddy N, et al.
Commun Med (Lond)
. 2024 Jun;
4(1):123.
PMID: 38918506
Background: Strategies toward HIV-1 cure aim to clear, inactivate, reduce, or immunologically control the virus from a pool of latently infected cells such that combination antiretroviral therapy (cART) can be...
3.
Jones R, Scholtes M, Goodspeed A, Akbarzadeh M, Mohapatra S, Feldman L, et al.
Cancer Res
. 2024 Mar;
84(10):1699-1718.
PMID: 38535994
Significance: Targeting NPEPPS, which induces cisplatin resistance by controlling intracellular drug concentrations, is a potential strategy to improve patient responses to platinum-based therapies and lower treatment-associated toxicities.
4.
Crespo R, Ne E, Reinders J, Meier J, Li C, Jansen S, et al.
iScience
. 2024 Feb;
27(3):109152.
PMID: 38384833
HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a subunit of the transcription...
5.
Prins H, Crespo R, Lungu C, Rao S, Li L, Overmars R, et al.
Sci Adv
. 2023 Mar;
9(11):eade6675.
PMID: 36921041
Reactivation of the latent HIV-1 reservoir is a first step toward triggering reservoir decay. Here, we investigated the impact of the BAF complex inhibitor pyrimethamine on the reservoir of people...
6.
Ne E, Crespo R, Izquierdo-Lara R, Rao S, Kocer S, Gorska A, et al.
Nucleic Acids Res
. 2022 May;
50(10):5577-5598.
PMID: 35640596
A major pharmacological strategy toward HIV cure aims to reverse latency in infected cells as a first step leading to their elimination. While the unbiased identification of molecular targets physically...
7.
Roling M, Sisakht M, Ne E, Moulos P, Crespo R, Stoszko M, et al.
mBio
. 2021 Dec;
12(6):e0298021.
PMID: 34872356
To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat). Following...
8.
De Crignis E, Hossain T, Romal S, Carofiglio F, Moulos P, Khalid M, et al.
Elife
. 2021 Jul;
10.
PMID: 34328417
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system. Here we propose the...
9.
Tilly B, Chalkley G, van der Knaap J, Moshkin Y, Kan T, Dekkers D, et al.
Elife
. 2021 Jul;
10.
PMID: 34313222
ATP-dependent chromatin remodelers control the accessibility of genomic DNA through nucleosome mobilization. However, the dynamics of genome exploration by remodelers, and the role of ATP hydrolysis in this process remain...
10.
Stoszko M, Al-Hatmi A, Skriba A, Roling M, Ne E, Crespo R, et al.
Sci Adv
. 2020 Aug;
6(33):eaba6617.
PMID: 32851167
A leading pharmacological strategy toward HIV cure requires "shock" or activation of HIV gene expression in latently infected cells with latency reversal agents (LRAs) followed by their subsequent clearance. In...