Tsunaki Higa
Overview
Explore the profile of Tsunaki Higa including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
12
Citations
96
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Mizoo T, Oka T, Sugahara O, Minato T, Higa T, Nakayama K
J Biochem
. 2025 Jan;
177(2):105-119.
PMID: 39743241
Cancer stem cells (CSCs) play a central role in cancer progression, therapy resistance, and disease recurrence. With the use of a quadruple-mutant mouse intestinal cancer organoid model and single-cell RNA-sequencing...
2.
Koga D, Nakayama S, Higa T, Nakayama K
Genes Cells
. 2024 Oct;
29(12):1264-1274.
PMID: 39394696
The mammalian p57 protein is a member of the CIP/KIP family of cyclin-dependent kinase inhibitors and plays an essential role in the development of multiple tissues during embryogenesis as well...
3.
Higa T, Nakayama K
Cancer Sci
. 2024 Feb;
115(5):1370-1377.
PMID: 38413370
Cancer stem cells (CSCs) are a long-lived and self-renewing cancer cell population that drives tumor propagation and maintains cancer heterogeneity. They are also implicated in the therapeutic resistance of various...
4.
Oka T, Higa T, Sugahara O, Koga D, Nakayama S, Nakayama K
Cancer Res
. 2023 Mar;
83(9):1393-1409.
PMID: 36880956
Significance: A quiescent p57+ subpopulation of intestinal CSCs is resistant to chemotherapy and can be targeted to effectively suppress the recurrence of intestinal cancer.
5.
Higa T, Okita Y, Matsumoto A, Nakayama S, Oka T, Sugahara O, et al.
Nat Commun
. 2022 Mar;
13(1):1500.
PMID: 35314700
Although the mammalian intestinal epithelium manifests robust regenerative capacity after various cytotoxic injuries, the underlying mechanism has remained unclear. Here we identify the cyclin-dependent kinase inhibitor p57 as a specific...
6.
Nakatsumi H, Oka T, Higa T, Shirane M, Nakayama K
Genes Cells
. 2018 May;
23(7):599-605.
PMID: 29845697
Mammalian target of rapamycin complex 1 (mTORC1) kinase is a master regulator of the cellular response to nutrition-related signals such as insulin and amino acids. mTORC1 is activated on the...
7.
Horinouchi T, Hoshi A, Harada T, Higa T, Karki S, Terada K, et al.
Br J Pharmacol
. 2015 Dec;
173(6):1018-32.
PMID: 26660861
Background And Purpose: Endothelin-1 (ET-1) reduces insulin-stimulated glucose uptake in skeletal muscle, inducing insulin resistance. Here, we have determined the molecular mechanisms underlying negative regulation by ET-1 of insulin signalling....
8.
Harada T, Horinouchi T, Higa T, Hoshi A, Higashi T, Terada K, et al.
Life Sci
. 2014 Apr;
104(1-2):24-31.
PMID: 24735959
Aims: Endothelin (ET) system plays a critical role in the development of insulin resistance and type 2 diabetes. In skeletal muscle, differentiation of myoblasts to myotubes is accompanied by the...
9.
Horinouchi T, Higashi T, Higa T, Terada K, Mai Y, Aoyagi H, et al.
Biochem Biophys Res Commun
. 2012 Oct;
428(2):252-8.
PMID: 23068106
Stromal interaction molecule 1 (STIM1) is the endoplasmic reticulum (ER) Ca(2+) sensor to control ER Ca(2+) levels. A recent study has shown that STIM1L, a new splice variant of STIM1,...
10.
Horinouchi T, Terada K, Higa T, Aoyagi H, Nishiya T, Suzuki H, et al.
J Pharmacol Sci
. 2011 Dec;
117(4):295-306.
PMID: 22129540
The purpose of this study is to identify transient receptor potential canonical (TRPC) channels responsible for receptor-operated Ca(2+) entry (ROCE) triggered by activation of endothelin type A receptor (ET(A)R) and...