Trudy F Ramlall
Overview
Explore the profile of Trudy F Ramlall including associated specialties, affiliations and a list of published articles.
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14
Citations
752
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Recent Articles
1.
Saotome K, McGoldrick L, Ho J, Ramlall T, Shah S, Moore M, et al.
Nat Struct Mol Biol
. 2024 Sep;
32(2):315-325.
PMID: 39313635
Activation of the chemokine receptor CXCR4 by its chemokine ligand CXCL12 regulates diverse cellular processes. Previously reported crystal structures of CXCR4 revealed the architecture of an inactive, homodimeric receptor. However,...
2.
Grasso E, Terakawa M, Lai A, Xie Y, Ramlall T, Freed J, et al.
J Mol Biol
. 2022 Jul;
435(1):167710.
PMID: 35777466
Complexins play a critical role in regulating SNARE-mediated exocytosis of synaptic vesicles. Evolutionary divergences in complexin function have complicated our understanding of the role these proteins play in inhibiting the...
3.
Zhao J, Zhu Y, Song X, Xiao Y, Su G, Liu X, et al.
Angew Chem Int Ed Engl
. 2019 Nov;
59(5):1818-1827.
PMID: 31692167
Prion-like transcellular spreading of tau in Alzheimer's Disease (AD) is mediated by tau binding to cell surface heparan sulfate (HS). However, the structural determinants for tau-HS interaction are not well...
4.
Snead D, Lai A, Wragg R, Parisotto D, Ramlall T, Dittman J, et al.
Front Mol Neurosci
. 2017 Jun;
10:154.
PMID: 28596722
Complexin is a small soluble presynaptic protein that interacts with neuronal SNARE proteins in order to regulate synaptic vesicle exocytosis. While the SNARE-binding central helix of complexin is required for...
5.
Wragg R, Snead D, Dong Y, Ramlall T, Menon I, Bai J, et al.
Neuron
. 2013 Jan;
77(2):323-34.
PMID: 23352168
Synapses continually replenish their synaptic vesicle (SV) pools while suppressing spontaneous fusion events, thus maintaining a high dynamic range in response to physiological stimuli. The presynaptic protein complexin can both...
6.
Dikiy I, Ramlall T, Eliezer D
Biomol NMR Assign
. 2012 Aug;
7(2):245-8.
PMID: 22918595
Protein-mediated cholesterol trafficking is central to maintaining cholesterol homeostasis in cells. START (Steroidogenic acute regulatory protein-related lipid transfer) domains constitute a sterol and lipid binding motif and the START domain...
7.
Mesmin B, Pipalia N, Lund F, Ramlall T, Sokolov A, Eliezer D, et al.
Mol Biol Cell
. 2011 Sep;
22(21):4004-15.
PMID: 21900492
Nonvesicular transport of cholesterol plays an essential role in the distribution and regulation of cholesterol within cells, but it has been difficult to identify the key intracellular cholesterol transporters. The...
8.
Khusial P, Vadla B, Krishnan H, Ramlall T, Shen Y, Ichikawa H, et al.
Oncotarget
. 2011 Feb;
1(3):198-209.
PMID: 21301049
Cell migration is an essential step in cancer invasion and metastasis. A number of orchestrated cellular events involving tyrosine kinases and signaling receptors enable cancer cells to dislodge from primary...
9.
Anderson V, Ramlall T, Rospigliosi C, Webb W, Eliezer D
Proc Natl Acad Sci U S A
. 2010 Oct;
107(44):18850-5.
PMID: 20947801
Because oligomers and aggregates of the protein α-synuclein (αS) are implicated in the initiation and progression of Parkinson's disease, investigation of various αS aggregation pathways and intermediates aims to clarify...
10.
Georgieva E, Ramlall T, Borbat P, Freed J, Eliezer D
J Biol Chem
. 2010 Jul;
285(36):28261-74.
PMID: 20592036
Alpha-synuclein (alphaS) is linked to Parkinson disease through its deposition in an amyloid fibril form within Lewy Body deposits, and by the existence of three alphaS point mutations that lead...