Trond Aasen
Overview
Explore the profile of Trond Aasen including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
2389
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Recent Articles
1.
Domingues N, Catarino S, Cristovao B, Rodrigues L, Carvalho F, Sarmento M, et al.
EMBO J
. 2024 Jul;
43(17):3627-3649.
PMID: 39044100
A robust and efficient cellular response to lysosomal membrane damage prevents leakage from the lysosome lumen into the cytoplasm. This response is understood to happen through either lysosomal membrane repair...
2.
Di Vito A, Mandrone M, Chiocchio I, Gorini F, Ravegnini G, Coschina E, et al.
Plants (Basel)
. 2024 May;
13(9).
PMID: 38732416
Novel treatments in gastrointestinal stromal tumors (GISTs) are essential due to imatinib resistance and the modest results obtained with multi-target tyrosine kinase inhibitors. We investigated the possibility that the hydroalcoholic...
3.
Totland M, Knudsen L, Rasmussen N, Omori Y, Sorensen V, Elster V, et al.
Cell Mol Life Sci
. 2024 Apr;
81(1):171.
PMID: 38597989
Intercellular communication via gap junctions has a fundamental role in regulating cell growth and tissue homeostasis, and its dysregulation may be involved in cancer development and radio- and chemotherapy resistance....
4.
Martins-Marques T, Witschas K, Ribeiro I, Zuzarte M, Catarino S, Ribeiro-Rodrigues T, et al.
Open Biol
. 2023 Oct;
13(11):230258.
PMID: 37907090
Classically associated with gap junction-mediated intercellular communication, connexin43 (Cx43) is increasingly recognized to possess non-canonical biological functions, including gene expression regulation. However, the mechanisms governing the localization and role played...
5.
Totland M, Omori Y, Sorensen V, Kryeziu K, Aasen T, Brech A, et al.
Biochim Biophys Acta Mol Basis Dis
. 2023 Jul;
1869(7):166812.
PMID: 37454772
Gap junctions are specialized regions of the plasma membrane containing clusters of channels that provide for the diffusion of ions and small molecules between adjacent cells. A fundamental role of...
6.
Di Vito A, Ravegnini G, Gorini F, Aasen T, Serrano C, Benuzzi E, et al.
Pharmacol Ther
. 2023 Jun;
248:108475.
PMID: 37302758
Gastrointestinal stromal tumors (GISTs) are rare mesenchymal sarcomas and the gold-standard treatment is represented by tyrosine kinase inhibitors (TKIs). Unfortunately, first-line treatment with the TKI imatinib usually promotes partial response...
7.
Martins-Marques T, Costa M, Catarino S, Simoes I, Aasen T, Enguita F, et al.
EMBO Rep
. 2022 May;
23(7):e54312.
PMID: 35593040
Through the exchange of lipids, proteins, and nucleic acids, extracellular vesicles (EV) allow for cell-cell communication across distant cells and tissues to regulate a wide range of physiological and pathological...
8.
Vargas-Accarino E, Herrera-Montavez C, Cajal S, Aasen T
Int J Mol Sci
. 2021 Jun;
22(9).
PMID: 34066490
There is an unmet need for simplified in vitro models of malignancy and metastasis that facilitate fast, affordable and scalable gene and compound analysis. "Adherent" cancer cell lines frequently release...
9.
10.
Tishchenko A, Azorin D, Vidal-Brime L, Munoz M, Arenas P, Pearce C, et al.
Cancers (Basel)
. 2020 Oct;
12(10).
PMID: 33003486
Connexin 43 (Cx43) forms gap junctions that mediate the direct intercellular diffusion of ions and small molecules between adjacent cells. Cx43 displays both pro- and anti-tumorigenic properties, but the mechanisms...