Tristan Lerbs
Overview
Explore the profile of Tristan Lerbs including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
221
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0
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Recent Articles
1.
Cui L, Fang Z, De Souza C, Lerbs T, Guan Y, Li I, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(10):e2217199120.
PMID: 36848564
COVID-19 remains a global pandemic of an unprecedented magnitude with millions of people now developing "COVID lung fibrosis." Single-cell transcriptomics of lungs of patients with long COVID revealed a unique...
2.
Griffin M, Borrelli M, Garcia J, Januszyk M, King M, Lerbs T, et al.
Sci Transl Med
. 2021 Sep;
13(609):eabb3312.
PMID: 34516825
Pathologic skin scarring presents a vast economic and medical burden. Unfortunately, the molecular mechanisms underlying scar formation remain to be elucidated. We used a hypertrophic scarring (HTS) mouse model in...
3.
Cui L, Moraga I, Lerbs T, Van Neste C, Wilmes S, Tsutsumi N, et al.
Proc Natl Acad Sci U S A
. 2021 Jan;
118(2).
PMID: 33384332
Thrombopoietin (TPO) and the TPO-receptor (TPO-R, or c-MPL) are essential for hematopoietic stem cell (HSC) maintenance and megakaryocyte differentiation. Agents that can modulate TPO-R signaling are highly desirable for both...
4.
Lerbs T, Cui L, King M, Chai T, Muscat C, Chung L, et al.
JCI Insight
. 2020 Aug;
5(16).
PMID: 32814713
Scleroderma is a devastating fibrotic autoimmune disease. Current treatments are partly effective in preventing disease progression but do not remove fibrotic tissue. Here, we evaluated whether scleroderma fibroblasts take advantage...
5.
Foster D, Marshall C, Gulati G, Chinta M, Nguyen A, Salhotra A, et al.
Nat Commun
. 2020 Aug;
11(1):4061.
PMID: 32792541
Adhesions are fibrotic scars that form between abdominal organs following surgery or infection, and may cause bowel obstruction, chronic pain, or infertility. Our understanding of adhesion biology is limited, which...
6.
Cui L, Chen S, Lerbs T, Lee J, Domizi P, Gordon S, et al.
Nat Commun
. 2020 Jun;
11(1):2795.
PMID: 32493933
The transcription factor JUN is highly expressed in pulmonary fibrosis. Its induction in mice drives lung fibrosis, which is abrogated by administration of anti-CD47. Here, we use high-dimensional mass cytometry...
7.
Lerbs T, Cui L, Muscat C, Saleem A, Van Neste C, Domizi P, et al.
Stem Cell Reports
. 2020 Mar;
14(4):603-613.
PMID: 32197115
Osteoporosis and osteoporotic fractures lead to decreased life quality and high healthcare costs. Current treatments prevent losses in bone mass and fractures to some extent but have side effects. Therefore,...
8.
Lerbs T, Bisht S, Scholch S, Pecqueux M, Kristiansen G, Schneider M, et al.
BMC Cancer
. 2017 Apr;
17(1):249.
PMID: 28388884
Background: Epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSC) contribute to tumour progression and metastasis. Assessment of transcription factors involved in these two mechanisms can help to identify new targets...
9.
Kahlert C, Lerbs T, Pecqueux M, Herpel E, Hoffmeister M, Jansen L, et al.
Int J Cancer
. 2015 May;
137(9):2104-13.
PMID: 25951369
Epithelial-to-mesenchymal transition (EMT) contributes significantly to tumor progression and metastasis. The assessment of EMT-associated transcription factors could be a promising approach to identify biomarkers and potential therapeutic targets in colorectal...