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Trina Basu

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Recent Articles
1.
Antonoudiou P, Basu T, Maguire J
Neuroinformatics . 2025 Mar; 23(2):23. PMID: 40032704
Despite the vast number of publications reporting seizures and the reliance of the field on accurate seizure detection, there is a lack of open-source software tools in the scientific community...
2.
Colmers P, Antonoudiou P, Basu T, Coleman E, He Y, Scapa G, et al.
eNeuro . 2025 Jan; 12(1). PMID: 39746805
Psychiatric disorders, including anxiety and depression, are highly comorbid in people with epilepsy. However, the mechanisms mediating the shared pathophysiology are currently unknown. There is considerable evidence implicating the basolateral...
3.
Basu T, Antonoudiou P, Weiss G, Coleman E, David J, Friedman D, et al.
eNeuro . 2024 Jun; 11(7). PMID: 38914464
Epilepsy is often comorbid with psychiatric illnesses, including anxiety and depression. Despite the high incidence of psychiatric comorbidities in people with epilepsy, few studies address the underlying mechanisms. Stress can...
4.
Antonoudiou P, Basu T, Maguire J
Res Sq . 2024 Jun; PMID: 38854086
Despite the vast number of seizure detection publications there are no validated open-source tools for automating seizure detection based on electrographic recordings. Researchers instead rely on manual curation of seizure...
5.
Colmers P, Antonoudiou P, Basu T, Scapa G, Fuller P, Maguire J
bioRxiv . 2023 Dec; PMID: 38106120
Significance Statement: Psychiatric illnesses and epilepsy are highly comorbid and negatively impact the quality of life of people with epilepsy. The pathophysiological mechanisms mediating the bidirectional relationship between mood disorders...
6.
Basu T, Maguire J, Salpekar J
Neurosci Lett . 2021 Jan; 746:135618. PMID: 33429002
Stress is a common seizure trigger in persons with epilepsy. The body's physiological response to stress is mediated by the hypothalamic-pituitary-adrenal (HPA) axis and involves a hormonal cascade that includes...
7.
Salpekar J, Basu T, Thangaraj S, Maguire J
Int Rev Neurobiol . 2020 May; 152:195-219. PMID: 32450996
Stress is ubiquitous in chronic medical conditions; however, the connections to psychiatric and neurologic conditions are not always clearly established. Epilepsy is a unique illness that is intimately intertwined with...
8.
Khan N, Schoenike B, Basu T, Grabenstatter H, Rodriguez G, Sindic C, et al.
PLoS One . 2020 Jan; 14(12):e0226733. PMID: 31891591
Complex neurological conditions can give rise to large scale transcriptomic changes that drive disease progression. It is likely that alterations in one or a few transcription factors or cofactors underlie...
9.
Ruhl D, Bomba-Warczak E, Watson E, Bradberry M, Peterson T, Basu T, et al.
Nat Commun . 2019 Aug; 10(1):3532. PMID: 31387992
The synaptotagmin (syt) proteins have been widely studied for their role in regulating fusion of intracellular vesicles with the plasma membrane. Here we report that syt-17, an unusual isoform of...
10.
Basu T, ORiordan K, Schoenike B, Khan N, Wallace E, Rodriguez G, et al.
Sci Rep . 2019 Mar; 9(1):5266. PMID: 30918308
Abnormal synaptic plasticity has been implicated in several neurological disorders including epilepsy, dementia and Autism Spectrum Disorder (ASD). Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disorder that manifests...