Toshiro Okazaki
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Explore the profile of Toshiro Okazaki including associated specialties, affiliations and a list of published articles.
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95
Citations
4603
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Recent Articles
1.
Honma N, Hatta I, Okazaki T, Tokudome Y
Chem Phys Lipids
. 2022 Oct;
249:105255.
PMID: 36279928
Sphingomyelin synthase (SMS) synthesizes sphingomyelin (SM) from ceramide (Cer), a precursor of Cer. The effects of SMS deficiency on stratum corneum (SC) barrier function and SC lamellar structure are unknown....
2.
Taniguchi M, Nagaya S, Yuyama K, Kotani A, Igarashi Y, Okazaki T
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142562
Ceramide levels controlled by the sphingomyelin (SM) cycle have essential roles in cancer cell fate through the regulation of cell proliferation, death, metastasis, and drug resistance. Recent studies suggest that...
3.
Fujita J, Taniguchi M, Hashizume C, Ueda Y, Sakai S, Kondo T, et al.
Mol Pharmacol
. 2022 Mar;
101(5):322-333.
PMID: 35273080
Ceramide is a bioactive sphingolipid that mediates ionizing radiation- and chemotherapy-induced apoptosis. Neocarzinostatin (NCS) is a genotoxic anti-cancer drug that induces apoptosis in response to DNA double-strand breaks (DSBs) through...
4.
Fujii Y, Taniguchi M, Nagaya S, Ueda Y, Hashizume C, Watanabe K, et al.
Blood Adv
. 2021 Sep;
5(20):4265-4277.
PMID: 34478523
Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. Here, we describe the hematologic phenotypes, such as reduced circulating platelets and dysfunctional...
5.
Taniguchi M, Okazaki T
Cell Signal
. 2021 Aug;
87:110119.
PMID: 34418535
Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of phosphatidylcholine to ceramide in mammals. Conversely, ceramide...
6.
Zhang X, Sakamoto W, Canals D, Ishibashi M, Matsuda M, Nishida K, et al.
FASEB J
. 2021 Jan;
35(2):e21287.
PMID: 33423335
Regulation of sphingolipid metabolism plays a role in cellular homeostasis, and dysregulation of these pathways is involved in cancer progression. Previously, our reports identified ceramide as an anti-metastatic lipid. In...
7.
Taniguchi M, Okazaki T
J Lipid Atheroscler
. 2020 Oct;
9(3):380-405.
PMID: 33024732
Ceramide and sphingomyelin (SM) are major components of the double membrane-bound sphingolipids. Ceramide is an essential bioactive lipid involved in numerous cell processes including apoptosis, necrosis, and autophagy-dependent cell death....
8.
Bestard-Escalas J, Maimo-Barcelo A, Lopez D, Reigada R, Guardiola-Serrano F, Ramos-Vivas J, et al.
Cancers (Basel)
. 2020 May;
12(5).
PMID: 32443825
Colorectal cancer (CRC) is the fourth leading cause of cancer death in the world. Despite the screening programs, its incidence in the population below the 50s is increasing. Therefore, new...
9.
Taniguchi M, Ueda Y, Matsushita M, Nagaya S, Hashizume C, Arai K, et al.
FASEB J
. 2020 Jan;
34(3):3838-3854.
PMID: 31970839
The tumor microenvironment (TME) formation involving host cells and cancer cells through cell adhesion molecules (CAMs) is essential for the multiple steps of cancer metastasis and growth. Sphingomyelin synthase 2...
10.
Matsumoto G, Hashizume C, Watanabe K, Taniguchi M, Okazaki T
Mol Med
. 2019 Dec;
25(1):56.
PMID: 31847800
Background: There are two isoforms of sphingomyelin synthase (SMS): SMS1 and SMS2. SMS1 is located in the Golgi apparatus only while SMS2 is located in both the plasma membrane and...