Toshinori Nakayama
Overview
Explore the profile of Toshinori Nakayama including associated specialties, affiliations and a list of published articles.
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Articles
319
Citations
10537
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Recent Articles
1.
Kaneko T, Iwamura C, Kiuchi M, Kurosugi A, Onoue M, Matsumura T, et al.
J Allergy Clin Immunol Glob
. 2024 Jul;
3(3):100287.
PMID: 39040657
Background: Massive eosinophil infiltration into the esophagus is associated with subepithelial fibrosis and esophageal stricture in patients with eosinophilic esophagitis (EoE). However, the pathogenesis of esophageal fibrosis remains unclear. Objective:...
2.
Aoki A, Iwamura C, Kiuchi M, Tsuji K, Sasaki A, Hishiya T, et al.
J Clin Immunol
. 2024 Apr;
44(4):104.
PMID: 38647550
Purpose: Auto-antibodies (auto-abs) to type I interferons (IFNs) have been identified in patients with life-threatening coronavirus disease 2019 (COVID-19), suggesting that the presence of auto-abs may be a risk factor...
3.
Hatano R, Lee E, Sato H, Kiuchi M, Hirahara K, Nakagawa Y, et al.
Mol Metab
. 2024 Apr;
84:101934.
PMID: 38604598
Objectives: During fasting, liver pivotally regulates blood glucose levels through glycogenolysis and gluconeogenesis. Kidney also produces glucose through gluconeogenesis. Gluconeogenic genes are transactivated by fasting, but their expression patterns are...
4.
Koura M, Kameoka Y, Kishi F, Yamakawa Y, Ito F, Sugamata R, et al.
Clin Exp Immunol
. 2023 Dec;
216(1):55-67.
PMID: 38156760
Based on the efficacy of intravenous immunoglobulin (IVIg) for the treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), we developed a recombinant single-chain-fragment variable clone, VasSF, therapeutic against AAV in...
5.
Kanno T, Miyako K, Endo T, Yokoyama S, Asou H, Yamada K, et al.
Int Immunol
. 2023 Dec;
36(3):129-139.
PMID: 38041796
To meet the energetic requirements associated with activation, proliferation, and survival, T cells switch their metabolic signatures from energetically quiescent to activated. However, little is known about the role of...
6.
Kumagai J, Kiuchi M, Kokubo K, Yagyu H, Nemoto M, Tsuji K, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(49):e2302903120.
PMID: 38015852
Uncontrolled type 2 immunity by type 2 helper T (Th2) cells causes intractable allergic diseases; however, whether the interaction of CD4 T cells shapes the pathophysiology of allergic diseases remains...
7.
Iwamura C, Ohnuki H, Flomerfelt F, Zheng L, Carletti A, Wakashin H, et al.
Nat Immunol
. 2023 Nov;
24(12):2080-2090.
PMID: 37957354
Aberrant differentiation of progenitor cells in the hematopoietic system is known to severely impact host immune responsiveness. Here we demonstrate that NOD1, a cytosolic innate sensor of bacterial peptidoglycan, also...
8.
Endo Y, Kanno T, Nakajima T, Ikeda K, Taketomi Y, Yokoyama S, et al.
Sci Immunol
. 2023 Aug;
8(86):eadd4346.
PMID: 37540735
Metabolic fluxes involving fatty acid biosynthesis play essential roles in controlling the differentiation of T helper 17 (T17) cells. However, the exact enzymes and lipid metabolites involved, as well as...
9.
Yuita H, Lopez-Moyado I, Jeong H, Cheng A, Scott-Browne J, An J, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(6):e2214824120.
PMID: 37406303
The three mammalian TET dioxygenases oxidize the methyl group of 5-methylcytosine in DNA, and the oxidized methylcytosines are essential intermediates in all known pathways of DNA demethylation. To define the...
10.
Maezawa Y, Endo Y, Kono S, Ohno T, Nakamura Y, Teramoto N, et al.
J Diabetes Investig
. 2023 Jun;
14(9):1136-1139.
PMID: 37293689
Psoriasis is a chronic inflammatory skin disease that is associated with obesity and myocardial infarction. Obesity-induced changes in lipid metabolism promote T helper 17 (Th17) cell differentiation, which in turn...