Torsten Wuestefeld
Overview
Explore the profile of Torsten Wuestefeld including associated specialties, affiliations and a list of published articles.
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28
Citations
3072
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Recent Articles
11.
Santamaria R, Ballester M, Garcia-Llorens G, Martinez F, Blazquez M, Ribes-Koninckx C, et al.
Sci Rep
. 2022 Feb;
12(1):2308.
PMID: 35145162
Autologous cell replacement therapy for inherited metabolic disorders requires the correction of the underlying genetic mutation in patient's cells. An unexplored alternative for females affected from X-linked diseases is the...
12.
Zender S, Nickeleit I, Wuestefeld T, Sorensen I, Dauch D, Bozko P, et al.
Cancer Cell
. 2016 Aug;
30(2):353-356.
PMID: 27505676
No abstract available.
13.
Dauch D, Rudalska R, Cossa G, Nault J, Kang T, Wuestefeld T, et al.
Nat Med
. 2016 May;
22(7):744-53.
PMID: 27213815
MYC oncoproteins are involved in the genesis and maintenance of the majority of human tumors but are considered undruggable. By using a direct in vivo shRNA screen, we show that...
14.
Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley C, et al.
Nat Cell Biol
. 2015 Oct;
17(10):1370.
PMID: 26419804
No abstract available.
15.
Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley C, et al.
Nat Cell Biol
. 2015 Aug;
17(9):1205-17.
PMID: 26280535
Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show...
16.
Rudalska R, Dauch D, Longerich T, McJunkin K, Wuestefeld T, Kang T, et al.
Nat Med
. 2014 Sep;
20(10):1138-46.
PMID: 25216638
In solid tumors, resistance to therapy inevitably develops upon treatment with cytotoxic drugs or molecularly targeted therapies. Here, we describe a system that enables pooled shRNA screening directly in mouse...
17.
Jedicke N, Struever N, Aggrawal N, Welte T, Manns M, Malek N, et al.
Hepatology
. 2014 Jan;
59(6):2299-308.
PMID: 24449466
Unlabelled: Acute liver failure remains a critical clinical condition, with high mortality rates, and increased apoptosis of hepatocytes represents a key event in the cause of liver failure. Alpha-1-antitrypsin (AAT)...
18.
Pellegrino R, Calvisi D, Neumann O, Kolluru V, Wesely J, Chen X, et al.
Hepatology
. 2013 Nov;
59(5):1886-99.
PMID: 24285179
Unlabelled: Mouse Double Minute homolog 4 (MDM4) gene up-regulation often occurs in human hepatocellular carcinoma (HCC), but the molecular mechanisms responsible for its induction remain poorly understood. Here we investigated...
19.
Carlos Acosta J, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton J, et al.
Nat Cell Biol
. 2013 Jun;
15(8):978-90.
PMID: 23770676
Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells implement a complex pro-inflammatory response termed the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence, activates immune surveillance and paradoxically...
20.
Zender S, Nickeleit I, Wuestefeld T, Sorensen I, Dauch D, Bozko P, et al.
Cancer Cell
. 2013 Jun;
23(6):784-95.
PMID: 23727022
The incidence of cholangiocellular carcinoma (CCC) is increasing worldwide. Using a transgenic mouse model, we found that expression of the intracellular domain of Notch 1 (NICD) in mouse livers results...