Tore Bleckwehl
Overview
Explore the profile of Tore Bleckwehl including associated specialties, affiliations and a list of published articles.
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13
Citations
322
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Recent Articles
1.
Bleckwehl T, Babler A, Tebens M, Maryam S, Nyberg M, Bosteen M, et al.
Nat Cardiovasc Res
. 2024 Dec;
4(1):26-44.
PMID: 39715784
Atherosclerosis is a pervasive contributor to ischemic heart disease and stroke. Despite the advance of lipid-lowering therapies and anti-hypertensive agents, the residual risk of an atherosclerotic event remains high, and...
2.
Hoeft K, Bleckwehl T, Schumacher D, Kim H, Meyer R, Long Q, et al.
Nat Commun
. 2024 Dec;
15(1):10612.
PMID: 39638798
Single cell RNA sequencing has provided unprecedented insights into the molecular cues and cellular heterogeneity underlying human disease. However, the high costs and complexity of single cell methods remain a...
3.
Amrute J, Luo X, Penna V, Yang S, Yamawaki T, Hayat S, et al.
Nature
. 2024 Oct;
635(8038):423-433.
PMID: 39443792
Inflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction. However, the molecular mechanisms driving immune-fibroblast cell communication in human cardiac disease remain unexplored and there are at...
4.
Li-Bao L, Diaz-Diaz C, Raiola M, Sierra R, Temino S, Moya F, et al.
Nat Commun
. 2024 May;
15(1):3931.
PMID: 38729993
MYC plays various roles in pluripotent stem cells, including the promotion of somatic cell reprogramming to pluripotency, the regulation of cell competition and the control of embryonic diapause. However, how...
5.
Hoeft K, Schaefer G, Kim H, Schumacher D, Bleckwehl T, Long Q, et al.
Cell Rep
. 2023 Feb;
42(2):112131.
PMID: 36807143
Fibrosis represents the common end stage of chronic organ injury independent of the initial insult, destroying tissue architecture and driving organ failure. Here we discover a population of profibrotic macrophages...
6.
Schreibing F, Hannani M, Kim H, Nagai J, Ticconi F, Fewings E, et al.
Front Immunol
. 2023 Jan;
13:1066176.
PMID: 36591270
Introduction: SARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic infection to severe illness. A detailed understanding of the immune response to SARS-CoV-2 is critical to unravel the causative...
7.
Bleckwehl T, Crispatzu G, Schaaf K, Respuela P, Bartusel M, Benson L, et al.
Nat Commun
. 2021 Oct;
12(1):5771.
PMID: 34599190
Germline specification in mammals occurs through an inductive process whereby competent cells in the post-implantation epiblast differentiate into primordial germ cells (PGC). The intrinsic factors that endow epiblast cells with...
8.
Crispatzu G, Rehimi R, Pachano T, Bleckwehl T, Cruz-Molina S, Xiao C, et al.
Nat Commun
. 2021 Jul;
12(1):4344.
PMID: 34272393
Poised enhancers (PEs) represent a genetically distinct set of distal regulatory elements that control the expression of major developmental genes. Before becoming activated in differentiating cells, PEs are already bookmarked...
9.
Pachano T, Sanchez-Gaya V, Ealo T, Mariner-Fauli M, Bleckwehl T, Asenjo H, et al.
Nat Genet
. 2021 Jun;
53(7):1036-1049.
PMID: 34183853
CpG islands (CGIs) represent a widespread feature of vertebrate genomes, being associated with ~70% of all gene promoters. CGIs control transcription initiation by conferring nearby promoters with unique chromatin properties....
10.
Bleckwehl T, Rada-Iglesias A
Curr Opin Cell Biol
. 2019 Jun;
61:1-8.
PMID: 31233905
In mammals, germline specification is induced during early embryogenesis when competent cells respond to extrinsic signals and form primordial germ cells (PGCs), the precursors of the gametes. The fusion of...