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Tonglin Zhang

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Recent Articles
1.
Li B, Tang Z, Budhkar A, Liu X, Zhang T, Yang B, et al.
bioRxiv . 2025 Feb; PMID: 39975319
Spatial transcriptomics (ST) technologies have revolutionized our understanding of cellular ecosystems. However, these technologies face challenges such as sparse gene signals and limited gene detection capacities, which hinder their ability...
2.
Li S, Zhang T, Yang F, Li X, Wang Z, Zhao D
Sensors (Basel) . 2024 Jul; 24(13). PMID: 39001147
With the development of data mining technology, the analysis of event-related potential (ERP) data has evolved from statistical analysis of time-domain features to data-driven techniques based on supervised and unsupervised...
3.
Huang H, Tang Z, Zhang T, Yang B, Song Q, Su J
IEEE Int Conf Smart Cloud . 2024 May; 2023:164-169. PMID: 38706555
Compared to supervised machine learning (ML), the development of feature selection for unsupervised ML is far behind. To address this issue, the current research proposes a stepwise feature selection approach...
4.
Tang Z, Zhang T, Song Q, Su J, Yang B
ACM BCB . 2024 May; 2023. PMID: 38694619
The irreversible and progressive atrophy by Alzheimer's Disease resulted in continuous decline in thinking and behavioral skills. To date, CNN classifiers were widely applied to assist the early diagnosis of...
5.
Tang Z, Liu X, Li Z, Zhang T, Yang B, Su J, et al.
Brief Bioinform . 2023 Oct; 24(6). PMID: 37798249
Spatial cellular authors heterogeneity contributes to differential drug responses in a tumor lesion and potential therapeutic resistance. Recent emerging spatial technologies such as CosMx, MERSCOPE and Xenium delineate the spatial...
6.
Tang Z, Li Z, Hou T, Zhang T, Yang B, Su J, et al.
Nat Commun . 2023 Sep; 14(1):5618. PMID: 37699885
Recent advances in high-throughput molecular imaging have pushed spatial transcriptomics technologies to subcellular resolution, which surpasses the limitations of both single-cell RNA-seq and array-based spatial profiling. The multichannel immunohistochemistry images...
7.
Tang Z, Liu X, Li Z, Zhang T, Yang B, Su J, et al.
bioRxiv . 2023 Aug; PMID: 37577665
Key Points: We have developed a novel graph-based domain adaption model named SpaRx, to reveal the heterogeneity of spatial cellular response to different types of drugs, which bridges the gap...
8.
Tang Z, Zhang T, Yang B, Su J, Song Q
Brief Bioinform . 2022 Dec; 24(1). PMID: 36545790
Cell-cell communications are vital for biological signalling and play important roles in complex diseases. Recent advances in single-cell spatial transcriptomics (SCST) technologies allow examining the spatial cell communication landscapes and...
9.
Zhang T, Lin G
Comput Stat Data Anal . 2021 Mar; 159:107217. PMID: 33723467
Generalized -means can be combined with any similarity or dissimilarity measure for clustering. Using the well known likelihood ratio or -statistic as the dissimilarity measure, a generalized -means method is...
10.
Ma Q, Zhang T, Chen L, Tang Q
Mitochondrial DNA B Resour . 2020 Dec; 5(3):3647-3649. PMID: 33367044
is an endemic species of genus in China. In this study, we sequenced the complete mito-genome of . The genome is 16,592 base pair (bp) in length, encoding 13 protein-coding...