Tong-Tong Ji
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Explore the profile of Tong-Tong Ji including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
92
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0
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Recent Articles
1.
Guo X, Wu J, Ji T, Wang M, Zhang S, Xiong J, et al.
Chem Sci
. 2025 Feb;
16(9):3953-3963.
PMID: 39906385
Epigenetic modifications in genomes play a crucial role in regulating gene expression in mammals. Among these modifications, 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are recognized as the fifth and sixth nucleobases...
2.
Gang F, Xie N, Wang M, Zhang S, Ji T, Liu W, et al.
Anal Chem
. 2024 Dec;
96(52):20559-20567.
PMID: 39681302
5-Methylcytosine (5mC) is the most significant DNA modification present in mammalian genomes. Understanding the roles of 5mC in diverse biological processes requires quantitative detection at single-base resolution. In this study,...
3.
Xie N, Wang M, Ji T, Guo X, Gang F, Hao Y, et al.
Chem Sci
. 2024 Jul;
15(26):10073-10083.
PMID: 38966352
Cytosine modifications, particularly 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), play crucial roles in numerous biological processes. Current analytical methods are often constrained to the separate detection of either 5mC or 5hmC,...
4.
Ding J, Li G, Xiong J, Liu F, Xie N, Ji T, et al.
Anal Chem
. 2024 Mar;
96(11):4726-4735.
PMID: 38450632
DNA cytosine methylation (5-methylcytosine, 5mC) is a predominant epigenetic modification that plays a critical role in a variety of biological and pathological processes in mammals. In active DNA demethylation, the...
5.
Xie N, Wang M, Chen W, Ji T, Guo X, Gang F, et al.
ACS Cent Sci
. 2024 Jan;
9(12):2315-2325.
PMID: 38161361
The epigenetic modification 5-hydroxymethylcytosine (5hmC) plays a crucial role in the regulation of gene expression. Although some methods have been developed to detect 5hmC, direct genome-wide mapping of 5hmC at...
6.
Guo X, Xie N, Chen W, Ji T, Xiong J, Feng T, et al.
Anal Chem
. 2023 Dec;
96(2):847-855.
PMID: 38159051
RNA molecules undergo various chemical modifications that play critical roles in a wide range of biological processes. ,-Dimethyladenosine (mA) is a conserved RNA modification and is essential for the processing...
7.
Ji T, Xie N, Ding J, Wang M, Guo X, Chen Y, et al.
Anal Chem
. 2023 May;
95(21):8384-8392.
PMID: 37192336
Chemical modifications in DNA have profound influences on the structures and functions of DNA. Uracil, a naturally occurring DNA modification, can originate from the deamination of cytosine or arise from...
8.
Wang M, Xie N, Chen K, Ji T, Xiong J, Guo X, et al.
Anal Chem
. 2022 Dec;
95(2):1556-1565.
PMID: 36563112
DNA methylation (5-methylcytosine, 5mC) is the most important epigenetic modification in mammals. Deciphering the roles of 5mC relies on the quantitative detection of 5mC at the single-base resolution. Bisulfite sequencing...
9.
Xiong J, Chen K, Xie N, Ji T, Yu S, Tang F, et al.
Anal Chem
. 2022 Oct;
94(44):15489-15498.
PMID: 36280344
DNA methylation (5-methylcytosine, 5mC) is the most prevalent epigenetic modification that is predominantly found in CG dinucleotides in mammalian genomes. In-depth investigation of the functions of 5mC heavily relies on...
10.
Xie N, Wang M, Ji T, Guo X, Ding J, Yuan B, et al.
Chem Sci
. 2022 Jul;
13(23):7046-7056.
PMID: 35774177
The discovery of 5-hydroxymethylcytosine (5hmC) in mammalian genomes is a landmark in epigenomics study. Similar to 5-methylcytosine (5mC), 5hmC is viewed as a critical epigenetic modification. Deciphering the functions of...