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Tomoyuki Tsukiyama

Explore the profile of Tomoyuki Tsukiyama including associated specialties, affiliations and a list of published articles. Areas
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Articles 32
Citations 687
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Recent Articles
1.
Moghe P, Belousov R, Ichikawa T, Iwatani C, Tsukiyama T, Erzberger A, et al.
Nat Cell Biol . 2025 Feb; 27(3):408-423. PMID: 39966670
Tissue patterning coordinates morphogenesis, cell dynamics and fate specification. Understanding how precision in patterning is robustly achieved despite inherent developmental variability during mammalian embryogenesis remains a challenge. Here, based on...
2.
Fabreges D, Corominas-Murtra B, Moghe P, Kickuth A, Ichikawa T, Iwatani C, et al.
Science . 2024 Oct; 386(6718):eadh1145. PMID: 39388574
How living systems achieve precision in form and function despite their intrinsic stochasticity is a fundamental yet ongoing question in biology. We generated morphomaps of preimplantation embryogenesis in mouse, rabbit,...
3.
Yano-Sakamoto K, Kitai Y, Toriu N, Yamamoto S, Mizuta K, Saitou M, et al.
Biochem Biophys Res Commun . 2024 May; 722:150155. PMID: 38795454
Runt-related transcription factor (RUNX) family members play critical roles in the development of multiple organs. Mammalian RUNX family members, consisting of RUNX1, RUNX2, and RUNX3, have distinct tissue-specific expression and...
4.
Sato A, Tsukiyama T, Komeno M, Iwatani C, Tsuchiya H, Kawamoto I, et al.
Sci Rep . 2023 Sep; 13(1):15649. PMID: 37730951
Familial hypercholesterolemia (FH) is an inherited autosomal dominant disorder that is associated with a high plasma level of low-density lipoprotein (LDL) cholesterol, leading to an increased risk of cardiovascular diseases....
5.
Takashima S, Okamura E, Ichiyama Y, Nishi K, Shimizu A, Watanabe C, et al.
Exp Anim . 2023 Sep; 73(1):93-100. PMID: 37661429
Exocyst is an octameric protein complex implicated in exocytosis. The exocyst complex is highly conserved among mammalian species, but the physiological function of each subunit in exocyst remains unclear. Previously,...
6.
Gyobu-Motani S, Yabuta Y, Mizuta K, Katou Y, Okamoto I, Kawasaki M, et al.
EMBO J . 2023 Mar; 42(9):e112962. PMID: 36929479
Human in vitro oogenesis provides a framework for clarifying the mechanism of human oogenesis. To create its benchmark, it is vital to promote in vitro oogenesis using a model physiologically...
7.
Watanabe C, Shibuya H, Ichiyama Y, Okamura E, Tsukiyama-Fujii S, Tsukiyama T, et al.
Life (Basel) . 2022 Nov; 12(11). PMID: 36362885
Angiogenesis is a process to generate new blood vessels from pre-existing vessels and to maintain vessels, and plays critical roles in normal development and disease. However, the molecular mechanisms underlying...
8.
Hikiami R, Morimura T, Ayaki T, Tsukiyama T, Morimura N, Kusui M, et al.
Sci Rep . 2022 Sep; 12(1):16030. PMID: 36163369
Genetic mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). Although mitochondrial dysfunction and stress granule have been crucially implicated in FUS proteinopathy, the molecular basis remains unclear....
9.
Mizuta K, Katou Y, Nakakita B, Kishine A, Nosaka Y, Saito S, et al.
EMBO J . 2022 Aug; 41(18):e110815. PMID: 35912849
In vitro oogenesis is key to elucidating the mechanism of human female germ-cell development and its anomalies. Accordingly, pluripotent stem cells have been induced into primordial germ cell-like cells and...
10.
Jayakumar V, Nishimura O, Kadota M, Hirose N, Sano H, Murakawa Y, et al.
Sci Data . 2021 Jun; 8(1):159. PMID: 34183680
Cynomolgus macaque (Macaca fascicularis) and common marmoset (Callithrix jacchus) have been widely used in human biomedical research. Long-standing primate genome assemblies used the human genome as a reference for ordering...