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Tomoko Yoshikawa

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Articles 31
Citations 387
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Recent Articles
1.
Yao Y, Pauls S, Foley D, Yoshikawa T, Honma S, Honma K, et al.
PLoS Comput Biol . 2025 Mar; 21(3):e1012855. PMID: 40048409
The suprachiasmatic nucleus (SCN), locus of a circadian clock, is a small nucleus of approximately 20,000 neurons that oscillate with a period of about 24 hours. While individual neurons produce...
2.
Tokunou T, Yoshikawa T, Yoshioka Y, Ando S
Sleep Biol Rhythms . 2024 Sep; 22(4):499-504. PMID: 39300984
Intermittent hypoxia in sleep apnea syndrome (SAS) patients increases the oxidative stress and can cause serious cardiovascular diseases such as hypertension or atherosclerotic diseases through endothelial dysfunction. The evaluation of...
3.
Yoshikawa T, Honma K, Shigeyoshi Y, Yamagata Y, Honma S
Eur J Neurosci . 2024 Apr; 60(2):3828-3842. PMID: 38571281
Ca/calmodulin-dependent protein kinase IIα (CaMKIIα) is widely expressed in the brain and is involved in various functions, including memory formation, mood and sleep. We previously reported that CaMKIIα is involved...
4.
Sawatari H, Yoshikawa T, Ando S
Sleep Biol Rhythms . 2024 Mar; 22(1):155-158. PMID: 38476849
This study evaluated the effect of zolpidem and lemborexant on sleep and morning symptoms in patients undergoing type-1 polysomnography for suspected sleep-disordered breathing based on questionnaires and polysomnography results. We...
5.
Morioka E, Miyamoto T, Tamogami S, Koketsu T, Kim J, Yoshikawa T, et al.
Neurosci Lett . 2022 Nov; 792:136954. PMID: 36347340
In mammals, daily physiological activities are regulated by a central circadian pacemaker located in the hypothalamic suprachiasmatic nucleus (SCN). Recently, an increasing number of studies have used diurnal grass rats...
6.
Fujioka A, Nagano M, Ikegami K, Masumoto K, Yoshikawa T, Koinuma S, et al.
Brain Res . 2022 Nov; 1798:148129. PMID: 36332665
The localization and function of synaptotagmin (syt)17 in the suprachiasmatic nucleus (SCN) of the brain, which is the master circadian oscillator, were investigated. The Syt17 mRNA-containing neurons were mainly situated...
7.
Morimoto T, Yoshikawa T, Nagano M, Shigeyoshi Y
PLoS One . 2022 Oct; 17(10):e0276372. PMID: 36256675
In mammals, the center of the circadian clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Many studies have suggested that there are multiple regions generating different circadian...
8.
Morioka E, Kasuga Y, Kanda Y, Moritama S, Koizumi H, Yoshikawa T, et al.
Cell Rep . 2022 May; 39(6):110787. PMID: 35545046
The mechanisms that generate robust ionic oscillation in circadian pacemaker neurons are under investigation. Here, we demonstrate critical functions of the mitochondrial cation antiporter leucine zipper-EF-hand-containing transmembrane protein 1 (LETM1),...
9.
Yoshikawa T, Pauls S, Foley N, Taub A, LeSauter J, Foley D, et al.
eNeuro . 2021 Aug; 8(5). PMID: 34385151
Biological neural networks operate at several levels of granularity, from the individual neuron to local neural circuits to networks of thousands of cells. The daily oscillation of the brain's master...
10.
Yoshikawa T, Hata J, Sakata S, Nagata T, Hirakawa Y, Hirooka Y, et al.
Circ J . 2021 Feb; 85(8):1365-1372. PMID: 33597325
Background: Atrial fibrillation (AF) is a common arrhythmia in the elderly, and causes complications such as cardioembolic stroke. Serum high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, has been...